A simple breath test for tuberculosis using ion mobility: A pilot study.

Sahota, Amandip S, Gowda, Ravi, Arasaradnam, Ramesh P, Daulton, Emma, Savage, Richard S, Skinner, Jim R, Adams, Emily ORCID: https://orcid.org/0000-0002-0816-2835, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Covington, James A (2016) 'A simple breath test for tuberculosis using ion mobility: A pilot study.'. Tuberculosis (Edinburgh, Scotland), Vol 99, pp. 143-146.

Text Adams-JAC-TB Paper submission 3-Aug-16.docx - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (366kB)

Abstract

Tuberculosis (TB) remains one of the world's major health burdens with 9.6 million new infections globally. Though considerable progress has been made in reduction of TB incidence and mortality, there is a continuous need for lower cost, simpler and more robust means of diagnosis. One method that may fulfil these requirements is in the area of breath analysis. In this study we analysed the breath of 21 patients with pulmonary or extra-pulmonary TB, recruited from a UK teaching hospital (University Hospital Coventry and Warwickshire) before or within 1 week of commencing treatment for TB. TB diagnosis was confirmed by reference tests (mycobacterial culture), histology or radiology. 19 controls were recruited to calculate specificity; these patients were all interferon-gamma release assay negative (T.SPOT(®).TB, Oxford Immunotec Ltd.). Whole breath samples were collected with subsequent chemical analysis undertaken by Ion Mobility Spectrometry. Our results produced a sensitivity of 81% and a specificity of 79% for all cases of TB (pulmonary and extra-pulmonary). Though lower than other studies analysing pulmonary TB alone, we believe that this technique shows promise, and a higher sensitivity could be achieved by further improving our sample capture methodology.

Item Type:	Article
Subjects:	WB Practice of Medicine > Diagnosis > General Diagnosis > WB 200 Physical diagnosis (General) WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WF Respiratory System > Tuberculosis > WF 300 Pulmonary tuberculosis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.tube.2016.05.005
Depositing User:	Mary Creegan
Date Deposited:	19 Aug 2016 15:22
Last Modified:	15 Jun 2018 09:55
URI:	https://archive.lstmed.ac.uk/id/eprint/6069

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