Stability of Dihydroartemisinin-Piperaquine Tablet Halves during Prolonged Storage under Tropical Conditions

Hodel, EvaMaria ORCID: https://orcid.org/0000-0001-5821-1685, Kaur, Harparkash and Terlouw, Dianne J ORCID: https://orcid.org/0000-0001-5327-8995 (2017) 'Stability of Dihydroartemisinin-Piperaquine Tablet Halves during Prolonged Storage under Tropical Conditions'. American Journal of Tropical Medicine and Hygiene, Vol 96, Issue 2, pp. 338-340.

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Abstract

Dihydroartemisinin-piperaquine (DP) is recommended for the treatment of uncomplicated malaria, used in efforts to contain artemisinin resistance, and increasingly considered for mass drug administration. Due to the narrow therapeutic dose range and available tablet strengths, the manufacturers and World Health Organization recommended regimens involve breaking tablets into halves to accurately dose children according to body weight. Use of tablet fractions in programmatic settings under tropical conditions requires a highly stable product, however, the stability of DP tablet fractions is unknown. We aged full and half Eurartesim® DP tablets in a stability chamber at 30°C and 70% humidity level. The active pharmaceutical ingredients dihydroartemisinin and piperaquine remained at ≥95% over the 3 months period of ageing in light and darkness. These findings are reassuring for DP, but highlight the need to assess drug stability under real-life settings during the drug development process, particularly for key drugs of global disease control programmes.

Item Type:	Article
Subjects:	QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.4269/ajtmh.16-0759
Depositing User:	Helen Wong
Date Deposited:	21 Oct 2016 13:34
Last Modified:	13 Sep 2019 13:10
URI:	https://archive.lstmed.ac.uk/id/eprint/6273

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