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Haemotixic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise

Slagboom, Julien, Kool, J, Harrison, Robert and Casewell, Nicholas ORCID: (2017) 'Haemotixic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise'. British Journal of Haematology, Vol 177, Issue 6, pp. 947-959.

Brit_jour_of_Haemotol_hemotoxic review final.Casewell. 2017.pdf - Accepted Version
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Snake venoms are mixtures of numerous proteinacious components that exert diverse functional activities on a variety of physiological targets. Because the toxic constituents found in venom vary from species to species, snakebite victims can present with a variety of life-threatening pathologies related to the neurotoxic, cytotoxic and haemotoxic effects of venom. Of the 1·8 million people envenomed by snakes every year, up to 125 000 die, while hundreds of thousands survive only to suffer with life-changing long-term morbidity. Consequently, snakebite is one of the world's most severe neglected tropical diseases. Many snake venoms exhibit strong haemotoxic properties by interfering with blood pressure, clotting factors and platelets, and by directly causing haemorrhage. In this review we provide an overview of the functional activities of haemotoxic venom proteins, the pathologies they cause in snakebite victims and how their exquisite selectivity and potency make them amenable for use as therapeutic and diagnostic tools relevant for human medicine.

Item Type: Article
Additional Information: Special Issue: Low to middle income countries (LMIC)
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins
WA Public Health > WA 100 General works
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General)
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 01 Mar 2017 10:48
Last Modified: 28 Sep 2018 15:13


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