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Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies

Marais, Ben J, Hemmskerk, Anna D, Marais, Suzaan S, van Crevel, Reinout, Rohlwick, Ursula, Caws, Maxine ORCID:, Meintjes, Graeme, Misra, Usha K, Mai, Nguyen T H, Ruslami, Rovina, Seddon, James A, Solomans, Regan, van Toorn, Ronald, Figaji, Anthony, McIlleron, Helen, Aarnoutse, Robert, Schoeman, Johan F, Wilinson, Robert J and Thwaites, Guy E (2017) 'Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies'. Clinical Infectious Diseases, Vol 64, Issue 4, pp. 501-509.

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Tuberculous meningitis (TBM) remains a major cause of death and disability in tuberculosis-endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results. We propose standardized methods for the conduct of TBM clinical research that were drafted at an international tuberculous meningitis research meeting organized by the Oxford University Clinical Research Unit in Vietnam. We propose a core dataset including demographic and clinical information to be collected at study enrollment, important aspects related to patient management and monitoring, and standardized reporting of patient outcomes. The criteria proposed for the conduct of observational and intervention TBM studies should improve the quality of future research outputs, can facilitate multicenter studies and meta-analyses of pooled data, and could provide the foundation for a global TBM data repository.

Item Type: Article
Subjects: QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WL Nervous System > WL 200 Meninges. Blood-brain barrier
WX Hospitals and Other Health Facilities > Hospital Administration > WX 150 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 15 Feb 2017 15:02
Last Modified: 15 Jun 2018 14:48


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