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Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.

Kondkar, Altaf A, Edward, Nikhil B, Kalantan, Hatem, Al-Kharashi, Abdullah S, Altuwaijri, Saleh, Mohamed, Gamal, Sultan, Tahira, Azad, Taif A and Abu-Amero, Khaled K (2017) 'Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients.'. Journal of negative results in biomedicine, Vol 16, Issue 3.

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To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG).


The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay.


The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls. The minor ‘C’ allele frequency was 49.4%, which was comparable to the Japanese population and higher than the Indian and Afro-Caribbean populations. Similarly, no significant association was found between genotypes and systemic diseases and health awareness/behavior domain variables. Importantly, glaucoma specific indices, such as intraocular pressure, cup/disc ratio and number of anti-glaucoma medication, also showed no statistically significant effect of genotypes within POAG cases.


Polymorphism rs540782 is not a risk factor for POAG in the Saudi cohort.

Item Type: Article
Subjects: WW Ophthalmology > WW 20 Research (General)
WW Ophthalmology > Eye Structures and their Diseases > WW 290 Glaucoma
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 24 Feb 2017 10:23
Last Modified: 06 Feb 2018 13:14


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