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Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.

Santos, Victor S, Gurgel, Ricardo Q, Cavalcante, Sandra M M, Kirby, Andrew, Café, Lilian P, Souto, Maria J, Dolabella, Silvio S, de Assis, Matheus R, Fumian, Tulio M, Miagostovich, Marize P, Cunliffe, Nigel A and Cuevas, Luis ORCID: (2017) 'Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil.'. Journal of Clinical Virology, Vol 88, pp. 33-38.

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Gastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus.


We describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction.

Study design

A cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced.


In total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend = 6.7; p = 0.009), was more frequent in rotavirus vaccinated and in younger children (p < 0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%).


Norovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > General Virus Diseases > WC 500 Virus diseases (General or not elsewhere classified)
WC Communicable Diseases > Virus Diseases > General RNA Virus Infections > WC 501 RNA virus infections (General or not elsewhere classified)
WS Pediatrics > WS 20 Research (General)
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 312 Diarrheal disorders
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 10 Mar 2017 14:47
Last Modified: 29 Oct 2017 02:02


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