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Duarte, Tonya Azevedo, Nery, Joilda Silva, Boechat, Neio, Pereira, Susan Martins, Simonsen, Vera, Oliveira, Martha, Gomes, Gabriela 
ORCID: https://orcid.org/0000-0002-1454-4979, Penha-Gonçalves, Carlos, Barreto, Mauricio Lima and Barbosa, Theolis
(2017)
'A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.'. The Brazilian journal of infectious diseases, Vol 21, Issue 3, pp. 317-324.
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Abstract
Introduction
The Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have rarely identified EAI. In this study, we describe the occurrence of the EAI family in Brazil.
Methods
EAI was identified in a systematic literature review of genetic diversity studies pertaining to M. tuberculosis in Brazil, as well as in a survey conducted in Salvador, Bahia, located in the northeastern region of this country.
Results
The EAI6-BGD1 spoligotyping family and the EAI5 Spoligotype International Type (SIT) 1983 clade were the most frequently reported, with wide distribution of this particular clade described in Brazil. The distribution of other EAI spoligotyping patterns with broader worldwide distribution was restricted to the southeastern region of the country.
Conclusions
EAI may be endemic at a low frequency in Brazil, with some clades indicating increased fitness with respect to this population.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 500 Genetic phenomena QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.bjid.2017.01.005 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 31 Mar 2017 10:24 |
| Last Modified: | 13 Sep 2019 16:04 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/6920 |
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