Ochomo, Eric, Chahilu, Mercy, Cook, Jackie, Kinyari, Teresa, Bayoh, Nabie M, West, Philippa, Kamau, Luna, Osangale, Ombok, Njagi, Kiambo, Mathenge, Evan, Muthami, Lawrence, Subramaniam, Krishanthi, Knox, Tessa, Mnavaza, Abraham, Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Kleinschmidt, Immo and Mbogo, Charles (2017) 'Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya'. Emerging Infectious Diseases, Vol 23, Issue 5.
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Abstract
Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance
Item Type: | Article |
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Subjects: | QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
Faculty: Department: | Biological Sciences > Vector Biology Department |
Digital Object Identifer (DOI): | https://doi.org/10.3201/eid2305.161315 |
Depositing User: | Daisy Byrne |
Date Deposited: | 14 Jun 2017 14:29 |
Last Modified: | 16 Sep 2019 09:17 |
URI: | https://archive.lstmed.ac.uk/id/eprint/7148 |
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