Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness

Allen, J. E., Adjei, O., Bain, O., Hoerauf, A., Hoffmann, W. H., Makepeace, Benjamin L., Schulz-Key, H., Tanya, V. N., Trees, Alexander J., Wanji, S. and Taylor, D. W. (2008) 'Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness'. PLoS Neglected Tropical Diseases, Vol 2, Issue 4, e217.

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Abstract

River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease.

Item Type:	Article
Subjects:	WW Ophthalmology > Diseases. Color Perception > WW 160 Eye infections. Hypersensitivity diseases (General or not elsewhere classified)
Faculty: Department:	Groups (2002 - 2012) > Veterinary Parasitology Group (2002-2008)
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pntd.0000217
Depositing User:	Ms Julia Martin
Date Deposited:	26 Jul 2010 13:55
Last Modified:	06 Feb 2018 13:00
URI:	https://archive.lstmed.ac.uk/id/eprint/716

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