Over expression of a cytochrome p450 (CYP6P9) in a major African malaria vector, Anopheles funestus, resistant to pyrethroids

Amenya, D. A., Naguran, R., Lo, T. C. M., Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, Spillings, B. L., Wood, O. R., Brooke, B. D., Coetzee, M. and Koekemoer, L. L. (2008) 'Over expression of a cytochrome p450 (CYP6P9) in a major African malaria vector, Anopheles funestus, resistant to pyrethroids'. Insect Molecular Biology, Vol 17, Issue 1, pp. 19-25.

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Abstract

Anopheles funestus Giles is one of the major African malaria vectors. It has previously been implicated in a major outbreak of malaria in KwaZulu/Natal, South Africa, during the period 1996 to 2000. The re-emergence of this vector was associated with monooxygenase-based resistance to pyrethroid insecticides. We have identified a gene from the monooxygenase CYP6 family, CYP6P9, which is over expressed in a pyrethroid resistant strain originating from Mozambique. Quantitative Real-Time PCR shows that this gene is highly over expressed in the egg and adult stages of the resistant strain relative to the susceptible strain but the larval stages showed almost no difference in expression between strains. This gene is genetically linked to a major locus associated with pyrethroid resistance in this A. funestus population.

Item Type:	Article
Uncontrolled Keywords:	p450 insecticide resistance mosquito insecticide resistance house-fly gambiae strain genes overexpression sequence mosquito cloning
Subjects:	WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Digital Object Identifer (DOI):	https://doi.org/10.1111/j.1365-2583.2008.00776.x
Depositing User:	Users 183 not found.
Date Deposited:	05 Jul 2010 11:03
Last Modified:	06 Dec 2024 14:46
URI:	https://archive.lstmed.ac.uk/id/eprint/718

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