A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days.

Wootton, Daniel G, Dickinson, Laura, Pertinez, Henry, Court, Joanne, Eneje, Odiri, Keogan, Lynne, Macfarlane, Laura, Wilks, Sarah, Gallagher, Jane, Woodhead, Mark, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 and Diggle, Peter J (2017) 'A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days.'. European Respiratory Journal, Vol 49, Issue 6, e1602170.

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Abstract

Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from pneumonia symptoms? How long does this recovery take? Which factors influence symptomatic recovery?We prospectively recruited patients at two hospitals in Liverpool, UK, into a longitudinal, observational cohort study and modelled symptom recovery from CAP. We excluded patients with cancer, immunosuppression or advanced dementia, and those who were intubated or palliated from admission. We derived a statistical model to describe symptom patterns.We recruited 169 (52% male) adults. Multivariable analysis demonstrated that the time taken to recover to baseline was determined by the initial severity of symptoms. Severity of symptoms was associated with comorbidity and was inversely related to age. The pattern of symptom recovery was exponential and most patients' symptoms returned to baseline by 10 days.These results will inform the advice given to patients regarding the resolution of their symptoms. The recovery model described here will facilitate the use of symptom recovery as an outcome measure in future clinical trials.

Item Type:	Article
Subjects:	WA Public Health > WA 20.5 Research (General) WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 202 Pneumonia (General or not elsewhere classified) WF Respiratory System > WF 140 Diseases of the respiratory system (General)
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1183/13993003.02170-2016
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	30 Jun 2017 09:35
Last Modified:	07 Jun 2022 11:10
URI:	https://archive.lstmed.ac.uk/id/eprint/7320

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