High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar

Spencer, Stephen A, Penney, James M. St. John, Russell, Hannah J., Howe, Anthony P., Linder, Cortland, Rakotomampianina, Andriamahitsisambatra L. D., Nandimbiniaina,, Anjara M., Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420 and Bustinduy, Amaya L. (2017) 'High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar'. Parasites & Vectors, Vol 10, Issue 307.

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Abstract

Background
A school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.

Methods
School-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study.

Results
Of 399 school-aged children screened, 93.7% were infected with S. mansoni based on CCA analysis. Kato-Katz analysis of stool revealed S. mansoni infection in 73.6% (215/ 292). Heavy infections (> 400 eggs per gram) were common (32.1%; 69/ 215), with a mean of 482 eggs per gram of stool. Moderate infection intensities were detected in 31.2% (67/ 215) and light infection intensities in 36.7% (79/ 215) of infected participants. No infection with S. haematobium was detected by urine filtration.

Conclusions
Intestinal schistosomiasis appears a considerable public health issue in this remote area of Madagascar where there is a pressing need for mass drug administration.

Item Type:	Article
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 320 Child Welfare. Child Health Services. WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis WS Pediatrics > WS 100 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1186/s13071-017-2249-7
Depositing User:	Stacy Murtagh
Date Deposited:	05 Jul 2017 15:06
Last Modified:	02 Dec 2019 12:53
URI:	https://archive.lstmed.ac.uk/id/eprint/7336

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