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Kohli, Mikashmi, Schiller, Ian, Dendukuri, Nandini, Ryan, Hannah, Dheda, Keertan, Denkinger, Claudia M, Schumacher, Samuel G and Steingart, Karen (2017) 'Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance'. Cochrane Database of Systematic Reviews, Vol 8, CD012768.
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Abstract
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:
To determine the diagnostic accuracy of Xpert® MTB/RIF for the detection of extrapulmonary TB by site of disease in people suspected of having extrapulmonary TB. The role of Xpert® MTB/RIF would be a replacement for standard practice.
To determine the diagnostic accuracy of Xpert® MTB/RIF for detection of rifampicin resistance in people suspected of having extrapulmonary TB. The role of Xpert® MTB/RIF would be an initial test for replacement for culture-based DST.
We plan to investigate the impact of covariates on heterogeneity in estimates of test accuracy across the included studies.
Detection of extrapulmonary TB
The covariates of interest are: HIV prevalence; condition of the specimen (fresh versus frozen); sample input volume (for liquid specimens); homogenization step (for tissue specimens); smear status of specimen; past history of TB; and prevalence of extrapulmonary TB. In addition, we plan to explore whether the WHO standard operating procedures for a given type of specimen were followed and can explain the observed heterogeneity in accuracy estimates. For TB meningitis we plan to investigate whether the use of a concentration step prior to the use of Xpert® MTB/RIF has an impact on accuracy estimates. In addition, for detection of lymph node TB, pleural TB, and TB meningitis, we plan to adjust accuracy estimates by applying a latent class meta-analysis model to account for the imperfect nature of culture as the reference standard.
Detection of rifampicin resistance detection
The covariate of interest is the prevalence of rifampicin resistance.
| Item Type: | Article |
|---|---|
| Subjects: | WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WF Respiratory System > Tuberculosis > WF 300 Pulmonary tuberculosis WF Respiratory System > Tuberculosis > WF 360 Drug therapy |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1002/14651858.cd012768 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 15 Sep 2017 13:20 |
| Last Modified: | 22 Nov 2018 10:17 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/7530 |
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