Paediatric and maternal schistosomiasis: shifting the paradigms.

Bustinduy, Amaya, Stothard, Russell ORCID: https://orcid.org/0000-0002-9370-3420 and Friedman, Jennifer F (2017) 'Paediatric and maternal schistosomiasis: shifting the paradigms.'. British Medical Bulletin, Vol 123, Issue 1, pp. 115-125.

Text Bustinduy BMB_Final.docx - Accepted Version Available under License Creative Commons Attribution. Download (3MB)

Abstract

In endemic areas, schistosomiasis causes both overt and subclinical disease in young children and their mothers, as well as in returned travellers. Key recently published literature. An action plan for paediatric schistosomiasis and female genital schistosomiasis (FGS) is needed with expanded access to praziquantel (PZQ) treatment required. Schistosomiasis-related morbidity is underappreciated. Present and future demand for PZQ treatment is bottlenecked, imbalanced and inequitable. Current dosing, treatment algorithms and access plans are suboptimal with treatment stalled during pregnancy. Raised dosing of PZQ (>40 mg/kg) is being explored in young children. Surveillance of female genital schistosomiasis FGS is increasing. Use of PZQ in pregnancy is safe and preventive chemotherapy guidelines are being revised in morbidity- and transmission-control settings. Shifting focus of population-level control to individual-case management. Detection and prevention of FGS within general health services and integration of PZQ treatment for women and children in antenatal clinics. Feasibility studies assessing alternative and expanded access to PZQ treatment to at-risk children and mothers and pregnant women.

Item Type:	Article
Uncontrolled Keywords:	HIV, female genital schistosomiasis, mass drug administration, praziquantel, pregnancy, preventive chemotherapy
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 253 Anthelmintics WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare WA Public Health > Health Problems of Special Population Groups > WA 320 Child Welfare. Child Health Services. WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1093/bmb/ldx028
SWORD Depositor:	JISC Pubrouter
Depositing User:	Stacy Murtagh
Date Deposited:	04 Oct 2017 14:30
Last Modified:	02 Dec 2019 12:53
URI:	https://archive.lstmed.ac.uk/id/eprint/7635

Statistics

View details

Actions (login required)

Edit Item