LSTM Home > LSTM Research > LSTM Online Archive

Prenatal smoking exposure and asymmetric fetal growth restriction

Delpisheh, Ali, Brabin, Loretta, Drummond, Sandra and Brabin, Bernard (2008) 'Prenatal smoking exposure and asymmetric fetal growth restriction'. Annals of Human Biology, Vol 35, Issue 6, pp. 573-583.

Full text not available from this repository.


Background: Prenatal smoking exposure causes intrauterine fetal growth restriction ( IUGR), although its effects on fetal proportionality are less clearly defined.
Aim: The present study assessed fetal proportionality in babies with IUGR using maternal salivary cotinine to indicate maternal smoking exposure.
Subjects and methods: A case-control study at the Liverpool Women's Hospital, UK of babies with asymmetric and symmetric IUGR and non-growth restricted babies was carried out.
Results: 270 white women including 90 IUGR cases and 180 controls were enrolled. Asymmetry presented in 52.2% of IUGR cases. Geometric mean maternal cotinine concentration was higher with asymmetric (p = 0.002) than symmetric IUGR (p = 0.07), when compared to controls. Maternal smoking exposure was independently associated with asymmetric IUGR (OR 2.4, 95% CI, 1.5-4.4, p <= 0.001). Maternal anaemia was more frequent in babies with symmetric IUGR (OR 1.9, 1.3-3.4, p = 0.002), but not in asymmetric babies. Rohrer's index ranged between 1.64 and 2.25 for asymmetric infants and significantly decreased with increasing maternal cotinine concentration in IUGR babies. Increased cotinine was not associated with shortened gestational age in IUGR babies.
Conclusions: Asymmetric IUGR occurred more frequently in heavy smokers. Stopping smoking even late in pregnancy may be beneficial for improved fetal outcomes. Symmetric IUGR was associated with maternal anaemia, highlighting the importance of prenatal nutritional status.

Item Type: Article
Uncontrolled Keywords: asymmetry iugr pregnancy smoking maternal smoking intrauterine growth gestational-age birth-weight cigarette-smoking pregnancy retardation cotinine outcomes infants
Subjects: WA Public Health > WA 20.5 Research (General)
WA Public Health > Air pollution > WA 754 Pollution and pollutants (incl. tobacco pollution; passive smoking)
WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General)
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI):
Depositing User: Pauline Anderson
Date Deposited: 24 Aug 2010 10:02
Last Modified: 06 Feb 2018 13:00


View details

Actions (login required)

Edit Item Edit Item