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Mefloquine for preventing malaria during travel to endemic areas

Tickell-Painter, Maya, Mayaan, Nicola, Saunders, Rachel, Pace, Cheryl and Sinclair, David (2017) 'Mefloquine for preventing malaria during travel to endemic areas'. Cochrane Database of Systematic Reviews, Vol 10, Issue CD006491.

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Mefloquine is one of four antimalarial agents commonly recommended for preventing malaria in travellers to malaria-endemic areas.
Despite its high efficacy, there is controversy about its psychological side effects.
To summarize the efficacy and safety of mefloquine used as prophylaxis for malaria in travellers.
Search methods
We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials
(CENTRAL), published on the Cochrane Library; MEDLINE; Embase (OVID); TOXLINE (
toxline.htm); and LILACS. We also searched the World Health Organization (WHO) International Clinical Trials Registry Platform
(ICTRP; and ( for trials in progress, using ’mefloquine’, ’Lariam’, and ’malaria’ as search terms. The search date was 22 June 2017.
Selection criteria
We included randomized controlled trials (for efficacy and safety) and non-randomized cohort studies (for safety). We compared prophylactic mefloquine with placebo, no treatment, or an alternative recommended antimalarial agent. Our study populations included all adults and children, including pregnant women.
Data collection and analysis
Two review authors independently assessed the eligibility and risk of bias of trials, extracted and analysed data. We compared dichotomous
outcomes using risk ratios (RR) with 95% confidence intervals (CI). Pre specified adverse outcomes are included in ’Summary of findings’ tables, with the best available estimate of the absolute frequency of each outcome in short-term international travellers. We assessed the certainty of the evidence using the GRADE approach.

Item Type: Article
Subjects: QS Anatomy > QS 4 General works. Classify here works on regional anatomy
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine.
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 13 Nov 2017 16:46
Last Modified: 30 Oct 2018 02:02


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