Tools
Tools
Riveron, Jacob 
ORCID: https://orcid.org/0000-0002-5395-767X, Watsenga, Francis, Irving, Helen, Irish, Seth R and Wondji, Charles ORCID: https://orcid.org/0000-0003-0791-3673
(2018)
'High Plasmodium Infection Rate and Reduced Bed Net Efficacy in Multiple Insecticide-Resistant Malaria Vectors in Kinshasa, Democratic Republic of Congo'. Journal of Infectious Disease, Vol 217, Issue 2, pp. 320-328.
|
Text
Journal_of_infectious_diseases_High Plasmodium infection rate.pdf - Accepted Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
|
|
Text
j_inf_dis_217_3_320-328_2018.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Accounting for approximately 11% of all malaria cases, the Democratic Republic of Congo (DRC) is central to malaria elimination efforts. To support vector control interventions in DRC, we characterized the dynamics and impact of insecticide resistance in major malaria vectors in 2015. High Plasmodium infection rates were recorded in An. gambiae and An. funestus with P. falciparum predominant over P. malariae. Both mosquito species exhibited high and multiple resistance to major public health insecticide classes. The extremely high resistance to permethrin and DDT in An. gambiae (low mortalities after 6 hours exposure) is worrisome, and is supported by a reduced insecticidal effect of bednets against both mosquito species in laboratory tests. Metabolic and target site insensitivity mechanisms are driving this resistance in An. gambiae but only the former was observed in An. funestus. These findings highlight the urgent need for actions to prolong the effectiveness of insecticide-based interventions in DRC.
| Item Type: | Article |
|---|---|
| Subjects: | QX Parasitology > Protozoa > QX 135 Plasmodia QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control WA Public Health > WA 30 Socioeconomic factors in public health (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/infdis/jix570 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 13 Nov 2017 16:23 |
| Last Modified: | 14 Oct 2019 08:54 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/7813 |
Statistics
Actions (login required)
 |
Edit Item |