Miles, Alistair, Harding, Nicholas J., Bottà, Giordano, Clarkson, Christopher S., RodriguesAntao, Tiago, Kozack, Krzysztof, Schrider, Daniel R., Kern, Andrew D., Redmond, Seth, Igor, Sharakov, Pearson, Richard D., Bergey, Christina, Fontaine, Michael C., Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Lawniczak, Mara K. N., Kwiatkowski, Dominic P., Ayala, Diego, Besansky, Nora J., Burt, Austin, Caputo, Beniamino, Torre, Alessandra della, Godfray, H. Charles J., Hahn, Matthew W., Midega, Janet, Neafsey, Daniel E., O'Loughlin, Samantha, Pinto, João, Riehle, Michelle M., Vernick, Kenneth D., Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Wilding, Craig, White, Bradley J., Troco, Arlete D., Diabaté, Abdoulaye, Costantini, Carlo, Rohatgi, Kyanne R., Elissa, Nohal, Coulibaly, Boubacar, Dinis, João, Mbogo, Charles, Bejon, Philip, Mawejje, Henry D., Stalker, Jim, Rockett, Kirk, Drury, Eleanor, Mead, Daniel, Jeffreys, Anna, Hubbart, Christina, Rowlands, Kate, Isaacs, Alison ORCID: https://orcid.org/0000-0002-2452-3338, Jyothi, Dushyanth, Malangone, Cinzia, Vauterin, Paul, Jeffery, Ben, Wright, Ian, Hart, Lee, Kluczynski, Krzysztof, Cornelius, Victoria, MacInnis, Bronwyn, Henrichs, Christa and Giacomantonio, Rachel (2017) 'Genetic diversity of the African malaria vector Anopheles gambiae'. Nature, Vol 552, pp. 96-100.
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Abstract
The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
Item Type: | Article |
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Corporate Authors: | The Anopheles gambiae 1000 Genomes Consortium |
Subjects: | QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control |
Faculty: Department: | Biological Sciences > Vector Biology Department |
Digital Object Identifer (DOI): | https://doi.org/10.1038/nature24995 |
Depositing User: | Daisy Byrne |
Date Deposited: | 19 Dec 2017 12:35 |
Last Modified: | 30 Nov 2020 13:17 |
URI: | https://archive.lstmed.ac.uk/id/eprint/7972 |
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