Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.

Scriven, James, Botha, FrancoiS, Schutz, Charlotte, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Wainwright, Helen and Meintjes, GraemE (2018) 'Paradoxical respiratory failure due to cryptococcal pneumonia after amphotericin B treatment for HIV-associated cryptococcal meningitis.'. Medical Mycology Case Reports, Vol 19, pp. 38-40.

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Abstract

We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms.

Item Type:	Article
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 252 Antifungal agents. Antifungal antibiotics WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 202 Pneumonia (General or not elsewhere classified) WC Communicable Diseases > Mycoses > WC 475 Cryptococcosis. Sporotrichosis WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WF Respiratory System > WF 140 Diseases of the respiratory system (General) WL Nervous System > WL 200 Meninges. Blood-brain barrier
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.mmcr.2017.02.004
Depositing User:	Stacy Murtagh
Date Deposited:	06 Feb 2018 10:44
Last Modified:	14 Dec 2020 15:52
URI:	https://archive.lstmed.ac.uk/id/eprint/8201

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