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Utility assessment of HIV/AIDS-related health states in HIV-infected Ugandans

Lara, Antonieta M., Wakholi, B. N., Kasirye, A., Munderi, P., Watera, C., Lalloo, David ORCID:, Haycox, A., Gilks, C.F. and Grosskurth, H. (2008) 'Utility assessment of HIV/AIDS-related health states in HIV-infected Ugandans'. AIDS, Vol 22, Issue Suppl. 1, S123-S130.

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Objective: To assess the psychometric performance Of using standard gamble (SG), time trade-off (TTO) and visual analogue scale (VAS) in the evaluation of three predetermined HIV/AIDS health states in HIV-infected Ugandans, for use in cost-effectiveness analyses.
Methods: We recruited participants with CD4 cells < 200/mu l from the Development of AntiRetroviral Therapy in Africa (DART) trial cohort [randomized trial evaluating antiretroviral therapy (ART) management strategies] in Uganda, before they initiated ART (n=276). A comparison group of ART-naive HIV-infected individuals was recruited from the Entebbe Cohort study (n=159). Participants were interviewed and asked to rate his/her own health state using VAS; rank and evaluate HIV/AIDS predetermined health states using TTO and SG relative to an improved health state. Tools were tested for psychometrical properties.
Results: Women Constituted 64% and 76% of the DART and Entebbe Cohorts. Mean age was 36.5 and 36.7 years, respectively. Participants Could discriminate between predetermined HIV/AIDS health states. Deterioration in health status was associated with a reduction in rating scores (VAS), increased willingness to give uptime (TTO) and acceptance of increased risk (SG) to achieve a better health state, independent of the participant's actual health state, as measured by CD4 cell counts.
Conclusion: VAS, TTO and SG have good psychometric properties, making them good candidates for use in resource-constrained settings. Further research in a wider population is necessary to generate an evidence base with which to inform resource allocation decisions. (C) 2008 Wolters Kluwer Health. Lippincott Williams & Wilkins.

Item Type: Article
Uncontrolled Keywords: hiv/aids standard gamble time trade-off visual analogue scale quality-of-life outcomes patient disease
Subjects: WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy
QV Pharmacology > QV 38 Drug action.
Digital Object Identifer (DOI):
Depositing User: Users 43 not found.
Date Deposited: 20 Jul 2010 13:43
Last Modified: 22 Jun 2018 09:24


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