Copy number variation (CNV) and insecticide resistance in mosquitoes: evolving knowledge or an evolving problem?

Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Djogbenou, Luc and Lucas, Eric ORCID: https://orcid.org/0000-0003-3892-1668 (2018) 'Copy number variation (CNV) and insecticide resistance in mosquitoes: evolving knowledge or an evolving problem?'. Current Opinion in Insect Science, Vol 27, pp. 82-88.

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Abstract

Copy number variation (CNV) in insect genomes is a rich source of potentially adaptive polymorphism which may help overcome the constraints of purifying selection on conserved genes and/or permit elevated transcription. Classic studies of amplified esterases and acetylcholinesterase duplication in Culex pipiens quantified evolutionary dynamics of CNV driven by insecticidal selection. A more complex and potentially medically impactful form of CNV is found in Anopheles gambiae, with both heterogeneous duplications and homogeneous amplifications strongly linked with insecticide resistance. Metabolic gene amplification, revealed by shotgun sequencing, appears common in Aedes aegypti, but poorly understood in other mosquito species. Many methodologies have been used to detect CNV in mosquitoes, but relatively few can detect both duplications and amplifications, and contrasting methods should be combined. Genome scans for CNV have been rare to date in mosquitoes, but offer immense potential to determine the overall role of CNV as a component of resistance mechanisms.sequencing, appears common in Aedes
aegypti, but poorly understood in other mosquito species. Many methodologies have been used to detect CNV in
mosquitoes, but relatively few can detect both duplications and amplifications, and contrasting methods should be
combined. Genome scans for CNV have been rare to date in mosquitoes, but offer immense potential to determine the
overall role of CNV as a component of resistance mechanisms.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 460 Genomics. Proteomics QU Biochemistry > Genetics > QU 475 Genetic processes QX Parasitology > QX 20 Research (General) QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.cois.2018.04.005
Depositing User:	Daisy Byrne
Date Deposited:	03 May 2018 10:56
Last Modified:	07 Sep 2019 13:08
URI:	https://archive.lstmed.ac.uk/id/eprint/8506

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