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The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes

Meredith, J. M., Hurd, H., Lehane, Mike and Eggleston, P. (2008) 'The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes'. Insect Molecular Biology, Vol 17, Issue 2, pp. 103-112.

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cDNAs of Anopheles gambiae Defensin 2 (AgDef2), Defensin 3 (AgDef3) and Defensin 4 (AgDef4), identified in the genome sequence, have been characterized and their expression profiles investigated. In contrast to both typical defensins and insect antimicrobial peptides generally, the newly identified defensins were not upregulated with acute-phase kinetics following immune challenge in insects or cell culture. However, mRNA abundance of AgDef2, AgDef3 and AgDef4 increased significantly during the larval stages. Promoter analysis of all three genes failed to identify putative immune response elements previously identified in other mosquito defensin genes. As previous studies failed to identify these larval-specific defensins, it seems likely that further antimicrobial peptide genes with nontypical expression profiles will be identified as more genome sequences become available.

Item Type: Article
Uncontrolled Keywords: defensin genes mosquito anopheles gambiae larval-specific antimicrobial peptide immune-responsive genes aedes-aegypti insect immunity molecular-cloning antibacterial protein antimicrobial peptide sapecin-b cell-line kappa-b transcriptional profiles
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI):
Depositing User: Users 183 not found.
Date Deposited: 11 Jun 2010 09:07
Last Modified: 06 Feb 2018 13:00


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