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Infectivity of Chronic Malaria Infections and Its Consequences for Control and Elimination

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Aguas, Ricardo, Maude, Richard J, Gomes, Gabriela ORCID: https://orcid.org/0000-0002-1454-4979, White, Lisa J, White, Nicholas J and Dondorp, Arjen M (2018) 'Infectivity of Chronic Malaria Infections and Its Consequences for Control and Elimination'. Clinical Infectious Diseases, Vol 67, Issue 2, pp. 295-302.

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Abstract

Assessing the importance of targeting the chronic Plasmodium falciparum malaria reservoir is pivotal as the world moves toward malaria eradication. Through the lens of a mathematical model, we show how, for a given malaria prevalence, the relative infectivity of chronic individuals determines what intervention tools are predicted be the most effective. Crucially, in a large part of the parameter space where elimination is theoretically possible, it can be achieved solely through improved case management. However, there are a significant number of settings where malaria elimination requires not only good vector control but also a mass drug administration campaign. Quantifying the relative infectiousness of chronic malaria across a range of epidemiological settings would provide essential information for the design of effective malaria elimination strategies. Given the difficulties obtaining this information, we also provide a set of epidemiological metrics that can be used to guide policy in the absence of such data.

Item Type:	Article
Subjects:	WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/cid/ciy055
SWORD Depositor:	JISC Pubrouter
Depositing User:	Stacy Murtagh
Date Deposited:	17 May 2018 13:14
Last Modified:	13 Sep 2019 16:05
URI:	https://archive.lstmed.ac.uk/id/eprint/8620

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