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Gametocytocidal drugs: taking the population perspective.

Graves, Patricia, Gelband, Hellen, Garner, Paul ORCID: and Choi, Leslie (2018) 'Gametocytocidal drugs: taking the population perspective.'. Lancet Infectious Diseases, Vol 18, Issue 7, p. 719.

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In their Article Dicko and colleagues1 state that both primaquine and methylene blue were “highly efficacious for preventing Plasmodium falciparum transmission” when given alongside primary malaria treatment, implying an effect on malaria transmission in the community. However, the trial measured the infectiousness of individuals to mosquitoes, which is several steps removed from the dynamics of disease transmission. Other trials have also measured whether individuals are less infectious to mosquitoes after treatment with a gametocytocidal agent, but none have measured an effect on transmission in the community, the outcome of real interest.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 20 Jul 2018 14:07
Last Modified: 21 Nov 2019 15:24


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