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Interferon Gamma, Interferon-Gamma-induced-Protein 10, and Tuberculin Responses of Children at High Risk of Tuberculosis Infection

Petrucci, R., Amer, N. A., Gurgel, R. Q., Sherchand, J. B., Doria, L., Lama, C., Ravn, P., Ruhwald, M., Yassin, Mohammed A., Harper, Gregory and Cuevas, Luis ORCID: (2008) 'Interferon Gamma, Interferon-Gamma-induced-Protein 10, and Tuberculin Responses of Children at High Risk of Tuberculosis Infection'. Pediatric Infectious Disease Journal, Vol 27, Issue 12, pp. 1073-1077.

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Background: Children in contact with adults with pulmonary tuberculosis (TB) are at risk for infection and disease progression, and chemoprophylaxis may reduce this risk. The identification of infection is based oil the tuberculin skill test (TST) and interferon-gamma (INF-gamma) release assays. Other biomarkers Such as interferon-gamma induced-protein 10 (IP-10) way have potential for the diagnosis of latent TB infections.
Objectives: To describe IP-10 concentrations and their association to TST and INF-gamma responses in children recently exposed to adults with smear-positive TB in Brazil and Nepal.
Methods: Two surveys using the same design were undertaken to describe TST, INF-gamma, and IP-10 responses in 146 children in Nepal and 113 children in Brazil.
Results: The concordance of TST and QuantiFERON-TB gold in-tube (QFT-IT) was high (kappa 0.73 in Brazil and 0.80 in Nepal). IP-10 responses were higher in children with both positive TST and positive QFT-IT (medians 1434 pg/mL in Brazil and 1402 pg/mL in Nepal) and lowest in children with both negative TST and negative QFT-IT (medians 206 pg/mL in Brazil and 81 pg/mL in Nepal). Children with negative TST and positive QFT-IT had higher IP-10 concentrations than children with positive TST but negative QFT-IT.
Conclusions: IP-10 is a potential marker to identify latent TB infections that is expressed in large quantities and with good agreement with QFT-IT. The reasons for the discrepant results observed are discussed.

Item Type: Article
Uncontrolled Keywords: interferon-gamma ip-10 latent tuberculosis children ifn-gamma cxc chemokines disease ip-10 cells diagnosis release esat-6 tests skin
Subjects: QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 800 Biological products producing immunity
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 141 Physical examination. Diagnosis. Mass screening. Monitoring
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 280 Respiratory system
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI):
Depositing User: Pauline Anderson
Date Deposited: 24 Aug 2010 13:56
Last Modified: 17 Jul 2020 10:57


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