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Insect cuticle: a critical determinant of insecticide resistance.

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Balabanidou, Vasileia, Grigoraki, Linta ORCID: https://orcid.org/0000-0001-8997-0406 and Vontas, John (2018) 'Insect cuticle: a critical determinant of insecticide resistance.'. Current Opinion in Insect Science, Vol 27, pp. 68-74.

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Abstract

Intense use of insecticides has resulted in the selection of extreme levels of resistance in insect populations. Therefore understanding the molecular basis of insecticide resistance mechanisms becomes critical. Penetration resistance refers to modifications in the cuticle that will eventually slow down the penetration of insecticide molecules within insects' body. So far, two mechanisms of penetration resistance have been described, the cuticle thickening and the altering of cuticle composition. Cuticular modifications are attributed to the over-expression of diversified genes or proteins, which belong to structural components (cuticular proteins mainly), enzymes that catalyze enzymatic reactions (CYP4G16 and laccase 2) or ABC transporters that promote cuticular translocation. In the present review we summarize recent studies and discuss future perspectives.

Item Type:	Article
Subjects:	QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.cois.2018.03.001
Depositing User:	Stacy Murtagh
Date Deposited:	09 Aug 2018 11:39
Last Modified:	24 Jul 2020 07:52
URI:	https://archive.lstmed.ac.uk/id/eprint/9012

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