C3b/iC3b Deposition on Streptococcus pneumoniae Is Not Affected by HIV Infection

Hyams, Catherine, Tam, Jerry C H, Brown, Jeremy S and Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 (2010) 'C3b/iC3b Deposition on Streptococcus pneumoniae Is Not Affected by HIV Infection'. PLoS ONE, Vol 5, Issue 1, e8902.

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Abstract

Streptococcus pneumoniae is a common cause of infection in both HIV positive patients and those with complement deficiencies. We hypothesised that HIV positive individuals might exhibit reduced opsonisation of pneumococcus with complement due to reduced levels of S. pneumoniae specific IgG. We discovered no difference in C3 deposition on S. pneumoniae between HIV positive or negative individuals, and furthermore C3 deposition remained unchanged as HIV progressed towards AIDS. We found no correlation between C3 deposition on S. pneumoniae and CD4 cell count in HIV infected individuals. Hence we have demonstrated no failure of complement immunity in HIV positive patients.

Item Type:	Article
Subjects:	WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pone.0008902
Depositing User:	Users 43 not found.
Date Deposited:	12 Apr 2010 15:47
Last Modified:	07 Oct 2019 08:23
URI:	https://archive.lstmed.ac.uk/id/eprint/953

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