Lynd, Amy ORCID: https://orcid.org/0000-0001-6054-0525, Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Barbosa, S., Egyir Yawson, A., Mitchell, Sara N., Pinto, J., Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X and Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497 (2010) 'Field, Genetic, and Modeling Approaches Show Strong Positive Selection Acting upon an Insecticide Resistance Mutation in Anopheles gambiae s.s.'. Molecular Biology and Evolution, Vol 27, Issue 5, p. 1117.
Full text not available from this repository.Abstract
Alleles subject to strong, recent positive selection will be swept toward fixation together with contiguous sections of the genome. Whether the genomic signatures of such selection will be readily detectable in outbred wild populations is unclear. In this study, we employ haplotype diversity analysis to examine evidence for selective sweeps around knockdown resistance (kdr) mutations associated with resistance to dichlorodiphenyltrichloroethane and pyrethroid insecticides in the mosquito Anopheles gambiae. Both kdr mutations have significantly lower haplotype diversity than the wild-type (nonresistant) allele, with kdr L1014F showing the most pronounced footprint of selection. We complement these data with a time series of collections showing that the L1014F allele has increased in frequency from 0.05 to 0.54 in 5 years,consistent with a maximum likelihood–fitted selection coefficient of 0.16 and a dominance coefficient of 0.25. Our data show that strong, recent positive selective events, such as those caused by insecticide resistance, can be identified in wild insect populations.
Item Type: | Article |
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Uncontrolled Keywords: | Anopheles gambiae, malaria, insecticide resistance, selection, knock-down resistance, genome |
Subjects: | QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QU Biochemistry > Genetics > QU 450 General Works QX Parasitology > Insects. Other Parasites > QX 515 Anopheles |
Faculty: Department: | Groups (2002 - 2012) > Vector Group |
Digital Object Identifer (DOI): | https://doi.org/10.1093/molbev/msq002 |
Depositing User: | Users 183 not found. |
Date Deposited: | 10 Jun 2010 16:00 |
Last Modified: | 19 Sep 2019 11:28 |
URI: | https://archive.lstmed.ac.uk/id/eprint/998 |
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