Items where LSTM Author is "Johnston, Kelly"

Article

Hoffmann, Guillaume, Lukarska, Maria, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Masters, Ellen, Johnston, Kelly, Ford, Louise, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Jensen, Malene Ringkjøbing and Palencia, Andrés (2024) 'Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.'. Science Advances, Vol 10, Issue 28, eado1453.

Quek, Shannon ORCID: https://orcid.org/0000-0002-1583-9541, Cook, Darren, Wu, Yang, Marriott, Amy, Steven, Andrew, Johnston, Kelly, Ford, Louise, Archer, John, Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Wagstaff, Simon ORCID: https://orcid.org/0000-0003-0577-5537, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2022) 'Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment'. Proceedings of the National Academy of Sciences, Vol 119, Issue 15, e2120003119.

Johnston, Kelly, Hong, W. David, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, O’Neill, Paul M., Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2021) 'Anti-Wolbachia drugs for filariasis'. Trends in Parasitology, Vol 37, Issue 12, pp. 1068-1081.

McGillan, Paul, Berry, Neil G., Nixon, Gemma L., Leung, Suet C., Webborn, Peter J. H., Wenlock, Mark C., Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cook, Darren, Johnston, Kelly, Ford, Louise, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Hong, David and O’Neill, Paul M. (2021) 'Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis'. ACS Medicinal Chemistry Letters, Vol 12, Issue 9, pp. 1421-1426.

Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Clark, Roger, Bardelle, Catherine, Harper, Paul, Collier, Matthew, Johnston, Kelly, Plant, Helen, Plant, Darren, McCall, Eileen, Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Ford, Louise, Murray, David, Rich, Kirsty, Wigglesworth, Mark, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2019) 'Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership'. SLAS Discovery, Vol 24, Issue 5, pp. 537-547.

Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, von Geldern, Thomas W, Ford, Louise, Hübner, Marc P, Marsh, Kennan, Johnston, Kelly, Sjoberg, Hanna, Specht, Sabine, Pionnier, Nicolas ORCID: https://orcid.org/0000-0002-2379-4945, Tyrer, Hayley, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cook, Darren, Murphy, Emma ORCID: https://orcid.org/0000-0001-9421-7777, Steven, Andrew, Archer, John, Bloemker, Dominique, Lenz, Franziska, Koschel, Marianne, Ehrens, Alexandra, Metuge, Haelly M, Chunda, Valerinne C, Ndongmo Chounna, Patrick W, Njouendou, Abdel J, Fombad, Fanny F, Carr, Robert, Morton, Howard E, Aljayyoussi, Ghaith, Hoerauf, Achim, Wanji, Samuel, Kempf, Dale J, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2019) 'Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis'. Science Translational Medicine, Vol 11, Issue 483.

von Geldern, Thomas W, Morton, Howard E, Clark, Rick F, Brown, Brian S, Johnston, Kelly, Ford, Louise, Specht, Sabine, Carr, Robert A, Stolarik, Deanne F, Ma, Junli, Rieser, Matthew J, Struever, Dominique, Frohberger, Stefan J, Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Hübner, Marc P, Hoerauf, Achim, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Marsh, Kennan and Kempf, Dale J (2019) 'Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.'. PLoS Neglected Tropical Diseases, Vol 13, Issue 2, e0007159.

Jacobs, Robert Toms, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric E, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A N, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case, Bakowski, Malina A, Turner, Joseph D ORCID: https://orcid.org/0000-0002-2185-5476, Taylor, Mark J ORCID: https://orcid.org/0000-0003-3396-9275 and Ward, Stephen A ORCID: https://orcid.org/0000-0003-2331-3192 (2019) 'Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.'. Journal of medicinal chemistry.

Hong, W David, Benayoud, Farid, Nixon, Gemma L, Ford, Louise, Johnston, Kelly, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cassidy, Andrew, Cook, Darren A N, Siu, Amy, Shiotani, Motohiro, Webborn, Peter J H, Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J, Ehrens, Alexandra, Hübner, Marc P, Hoerauf, Achim, Roberts, Adam ORCID: https://orcid.org/0000-0002-0760-3088, Hubbard, Alasdair ORCID: https://orcid.org/0000-0001-6668-9179, Tate, Edward W, Serwa, Remigiusz A, Leung, Suet C, Qie, Li, Berry, Neil G, Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M (2019) 'AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis.'. Proceedings of the National Academy of Sciences of the United States of America, Vol 116, Issue 4, pp. 1414-1419.

Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Bardelle, Catherine, Harper, Paul, Hong, Weiqian, Borjesson, Ulf, Johnston, Kelly, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren, Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma, Slatko, Barton, Cantin, Lindsey, Wu, Bo, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil, O'Neill, Paul, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2019) 'Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides'. Nature Communications, Vol 10, Issue 11.

Aljayyoussi, Ghaith, Tyrer, Hayley, Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas ORCID: https://orcid.org/0000-0002-2379-4945, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren, Steven, Andrew, Sharma, Raman, Guimaraes, Ana, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cassidy, Andrew, Johnston, Kelly, Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2018) 'Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.'. Scientific Reports, Vol 8, Issue 1, p. 1384.

Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Sharma, Raman, Aljayyoussi, Ghaith, Tyrer, Hayley, Gamble, Jo, Hayward, Laura, Priestley, Richard, Murphy, Emma ORCID: https://orcid.org/0000-0001-9421-7777, Davies, Jill, Waterhouse, David, Cook, Darren, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cassidy, Andrew, Steven, Andrew, Johnston, Kelly, Ford, Louise, Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2017) 'Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis'. Proceedings of the National Academy of Sciences of the United States of America, Vol 114, Issue 45, E9712-E9721.

Johnston, Kelly, Cook, Darren, Berry, Neil, Hong, Weiqian David, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Goddard, Megan, Ford, Louise, Nixon, Gemma, O'Neill, Paul, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2017) 'Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library'. Science Advances, Vol 3, Issue 9, eaao1551.

Aljayyoussi, Ghaith, Tyrer, Hayley, Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas ORCID: https://orcid.org/0000-0002-2379-4945, Waterhouse, David, Davies, Jill, Gamble, Jo, Metugene, Haelly, Cook, Darren, Steven, Andrew, Sharma, Raman, Guimaraes, Ana, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cassidy, Andrew, Johnston, Kelly, Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2017) 'Short Course, High Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis'. Scientific Reports, Vol 7, Issue 210.

Tamarozzi, Francesca, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Pionnier, Nicolas ORCID: https://orcid.org/0000-0002-2379-4945, Midgley, Angela, Guimaraes, Ana, Johnston, Kelly, Edwards, Steven W and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2016) 'Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis'. Scientific Reports, Vol 6, p. 35559.

Sharma, Raman, Aljayyoussi, Ghaith, Tyrer, Hayley, Gamble, Jo, Hayward, Laura, Guimaraes, Ana, Davies, Jill, Waterhouse, David, Cook, Darren, Myhill, Laura, Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cassidy, Andrew, Steven, Andrew, Johnston, Kelly, Ford, Louise, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2016) 'Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis'. Scientific Reports, Vol 6, p. 23458.

Johnston, Kelly, Ford, Louise, Umareddy, Indira, Townson, Simon, Specht, Sabine, Pfarr, Kenneth, Hoerauf, Achim, Altmeyer, Ralf and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2014) 'Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis'. International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Issue 3, pp. 278-286.

Voronin, Denis, Guimaraes, Ana, Molyneux, Gemma, Johnston, Kelly, Ford, Louise and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2014) 'Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus'. Parasites & Vectors, Vol 7, e462.

Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Cook, Darren, Johnston, Kelly, Ford, Louise, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2014) 'Development and Validation of a High-Throughput Anti-Wolbachia Whole-Cell Screen: A Route to Macrofilaricidal Drugs against Onchocerciasis and Lymphatic Filariasis'. Journal of Biomolecular Screening, Vol 20, Issue 1, pp. 64-69.

Tamarozzi, Francesca, Wright, Helen L, Johnston, Kelly, Edwards, Steven W, Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476 and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2014) 'Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro.'. Parasite Immunology, Vol 36, Issue 10, pp. 494-502.

Foster, Jeremy M, Landmann, Frédéric, Ford, Louise, Johnston, Kelly, Elsasser, Sarah C, Schulte-Hostedde, Albrecht I, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Slatko, Barton E (2014) 'Absence of Wolbachia endobacteria in the human parasitic nematode Dracunculus medinensis and two related Dracunculus species infecting wildlife'. Parasites & Vectors, Vol 7, e140.

Johnston, Kelly, Ford, Louise and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2013) 'Overcoming the Challenges of Drug Discovery for Neglected Tropical Diseases: The AWOL Experience'. Journal of Biomolecular Screening, Vol 19, Issue 3, pp. 335-343.

Ioannidis, Panagiotis, Johnston, Kelly, Riley, David R, Kumar, Nikhil, White, James R, Olarte, Karen T, Ott, Sandra, Tallon, Luke J, Foster, Jeremy M, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Dunning Hotopp, Julie C (2013) 'Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi'. BMC Genomics, Vol 14, :639.

Vollmer, Jennifer, Schiefer, Andrea, Schneider, Tanja, Jülicher, Karen, Johnston, Kelly, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Sahl, Hans-Georg, Hoerauf, Achim and Pfarr, Kenneth (2013) 'Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes.'. International Journal of Medical Microbiology, Vol 303, Issue 3, pp. 140-149.

Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Voronin, Denis, Johnston, Kelly and Ford, Louise (2013) 'Wolbachia filarial interactions.'. Cellular microbiology, Vol 15, Issue 4, pp. 520-26.

Schiefer, A., Schmitz, A., Schaberle, T. F., Specht, S., Lammer, C., Johnston, Kelly, Vassylyev, D. G., Konig, G. M., Hoerauf, A. and Pfarr, K. (2012) 'Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo'. Journal of Infectious Disease, Vol 206, Issue 2, pp. 249-257.

Johnston, Kelly, Wu, Bo, Guimarães, Ana, Ford, Louise, Slatko, Barton E and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2010) 'Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes'. Parasites & Vectors, Vol 3, e99.

Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Tendongfor, Nicholas, Esum, Mathias, Johnston, Kelly, Langley, R. Stuart, Ford, Louise, Faragher, Brian, Specht, Sabine, Mand, Sabine, Hoerauf, Achim, Enyong, Peter, Wanji, Samuel and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2010) 'Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial.'. PLoS Neglected Tropical Diseases, Vol 4, Issue 4, e660.

Henrichfreise, B., Schiefer, A., Schneider, T., Nzukou, E., Poellinger, C., Hoffmann, T. J., Johnston, Kelly, Moelleken, K., Wiedemann, L., Pfarr, K., Hoerauf, A. and Sahl, H. G. (2009) 'Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria chlamydia and wolbachia: Why is lipid II needed?'. Molecular Microbiology, Vol 73, Issue 5, pp. 913-923.

Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Langley, R. Stuart, Johnston, Kelly, Gentil, Katrin, Ford, Louise, Wu, Bo, Graham, Maia, Sharpley, Faye, Slatko, Barton, Pearlman, Eric and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2009) 'Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.'. The Journal of biological chemistry, Vol 284, Issue 33, pp. 22364-22378.

Johnston, Kelly, Wu, B., Guimaraes, A., Ford, Louise, Ambrose, Pauline, Slatko, B. E. and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2008) 'Globomycin: A New Class of Drug with Efficacy against Wolbachia and Filarial Nematodes'. American Journal of Tropical Medicine and Hygiene, Vol 79, Issue 6 Sup., p. 128.

Ford, Louise, Johnston, Kelly, Ambrose, P. A., Draper, M. P., Bhatia, B. and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2008) 'A-Wol Drug Discovery - Screening of Novel Derivatives of Tetracycline with Improved Efficacy over Doxycycline in an in Vitro Wolbachia Cell-Line Assay'. American Journal of Tropical Medicine and Hygiene, Vol 79, Issue 6, p. 128.

Foster, J. M., Kumar, S., Ford, Louise, Johnston, Kelly, Ben, R., Graeff-Teixeira, C. and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2008) 'Absence of Wolbachia endobacteria in the non-filariid nematodes Angiostrongylus cantonensis and A. costaricensis'. Parasites & Vectors, Vol 1, e31.

Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Langley, R. Stuart, Johnston, Kelly, Egerton, Gillian, Wanji, S. and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2006) 'Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner'. Journal of Immunology, Vol 177, Issue 2, pp. 1240-1249.

Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Langley, R. Stuart, Johnston, Kelly, Egerton, Gillian, Howard, R., Wanji, S. and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2005) 'Filarial Wolbachia endosymbiotic bacteria mediate macrophage tolerance to TLR and CD40 stimuli in a MyD88 dependent manner'. Immunology, Vol 116, Issue supp 1, p. 24.