Items where Subject is "QV Pharmacology > QV 34 Experimental pharmacology (General)"

Article

Adjuik, M., Agnamey, P., Babiker, A., Borrmann, S., Brasseur, P., Cisse, M., Cobelens, F., Diallo, S., Faucher, J. F., Garner, Paul ORCID: https://orcid.org/0000-0002-0607-6941, Gikunda, S., Kremsner, P. G., Krishna, S., Lell, B., Loolpapit, M., Matsiegui, P. B., Missinou, M. A., Mwanza, J., Ntoumi, F., Olliaro, P., Osimbo, P., Rezbach, P., Some, E. and Taylor, W. R. J. (2002) 'Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial'. Lancet, Vol 359, Issue 9315, pp. 1365-1372.

Alker, Alisa P., Juliano, Jonathan J., Meshnick, Steven R., Owen, Andrew, Ochong, Edwin, Bell, David J., Johnson, David, d'Alessandro, Umberto, Mulenga, Modest, Muangnoicharoen, Sant, Van Geertruyden, J. P., Winstanley, Peter A., Bray, Patrick and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2009) 'Plasmodium falciparum and Dihydrofolate Reductase I164L Mutations in Africa Reply'. Antimicrobial Agents and Chemotherapy, Vol 53, Issue 4, pp. 1722-1723.

Amewu, R., Stachulski, A. V., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Berry, N. G., Bray, Patrick, Davies, Jill, Labat, G., Vivas, L. and O'Neill, P. M. (2006) 'Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin'. Organic & Biomolecular Chemistry, Vol 4, Issue 24, pp. 4431-4436.

Amewu, R., Stachulski, A. V., Berry, N. G., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Davies, Jill, Labat, G., Rossignol, J. F. and O'Neill, P. M. (2006) 'Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology'. Bioorganic & Medicinal Chemistry Letters, Vol 16, Issue 23, pp. 6124-6130.

Barton, Victoria, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Chadwick, James, Hill, Alasdair and O'Neill, Paul M (2010) 'Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics.'. Journal of medicinal chemistry, Vol 53, Issue 11, pp. 4555-4559.

Bockarie, Moses and Deb, Rinki (2010) 'Elimination of lymphatic filariasis: do we have the drugs to complete the job?'. Current Opinion in Infectious Diseases, Vol 23, Issue 6, pp. 617-620.

Carballar-Lejarazú, R, Rodríguez, M H, de la Cruz Hernández-Hernández, F, Ramos-Castañeda, J, Possani, L D, Zurita-Ortega, M, Reynaud-Garza, E, Hernández-Rivas, R, Loukeris, T, Lycett, Gareth ORCID: https://orcid.org/0000-0002-2422-053X and Lanz-Mendoza, H (2008) 'Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens.'. Cellular and molecular life sciences : CMLS, Vol 65, Issue 19, pp. 3081-3092.

Chadwick, James, Jones, Michael, Mercer, Amy E, Stocks, Paul A., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Park, B Kevin and O'Neill, Paul M (2010) 'Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.'. Bioorganic and Medicinal Chemistry, Vol 18, Issue 7, pp. 2586-97.

Copple, Ian M, Mercer, Amy E, Firman, James, Donegan, Gail, Herpers, Bram, Wong, Michael Hl, Chadwick, James, Bringela, Andreia D, Cristiano, Maria L S, van de Water, Bob, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, O'Neill, Paul M and Park, B Kevin (2012) 'Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.'. Molecular medicine (Cambridge, Mass.), Vol 18, pp. 1045-55.

Debrah, A. Y., Mand, S., Specht, S., Marfo-Debrekyei, Y., Batsa, L., Pfarr, K., Larbi, J., Lawson, B., Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Adjei, O. and Hoerauf, A. (2006) 'Doxycycline reduces plasma VEGF-c/sVEGFR-3 and improves pathology in lymphatic filariasis'. PLoS Pathogens, Vol 2, Issue 9, e92.

Edwards, Geoffrey, Awadzi, K., Duke, B. O. L., Opoku, N. O., Attah, S. K., Addy, E. T., Ardrey, A. E. and Quartey, B. T. (2003) 'The co-administration of ivermectin and albendazole safety, pharmacokinetics and efficacy against Onchocerca volvulus'. Annals of Tropical Medicine and Parasitology, Vol 97, Issue 2, pp. 165-178.

Ford, Louise, Johnston, Kelly, Ambrose, P. A., Draper, M. P., Bhatia, B. and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2008) 'A-Wol Drug Discovery - Screening of Novel Derivatives of Tetracycline with Improved Efficacy over Doxycycline in an in Vitro Wolbachia Cell-Line Assay'. American Journal of Tropical Medicine and Hygiene, Vol 79, Issue 6, p. 128.

Gao, Chao, Zhu, Bin, Liu, Jianzheng, Jiang, Zhiwei, Hu, Tao, Wang, Qiong, Liu, Yi, Yuan, Ming, Li, Fei, Zhang, Ruining, Xia, Jielai, Onuma, Yoshinobu, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Serruys, Patrick and Tao, Ling (2024) 'Randomized evaluation of 5-month Ticagrelor monotherapy after 1-month dual-antiplatelet therapy in patients with acute coronary syndrome treated with drug-coated balloons: REC-CAGEFREE II trial rationale and design'. BMC Cardiovascular Disorders, Vol 24, Issue 1, e62.

Gibbons, Peter, Verissimo, Edite, Araujo, Nuna C, Barton, Victoria, Nixon, Gemma L, Amewu, Richard K, Chadwick, James, Stocks, Paul A., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Srivastava, Abhishek, Rosenthal, Philip J, Gut, Jiri, Guedes, Rita C, Moreira, Rui, Sharma, Raman, Berry, Neil, Cristiano, M Lurdes S, Shone, Alison, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M (2010) 'Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.'. Journal of medicinal chemistry, Vol 53, Issue 22, pp. 8202-6.

Hartkoorn, R. C., Chandler, B., Owen, A., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, Back, D. J. and Khoo, S. H. (2007) 'Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein'. Tuberculosis, Vol 87, Issue 3, pp. 248-255.

Johnston, Kelly, Ford, Louise, Umareddy, Indira, Townson, Simon, Specht, Sabine, Pfarr, Kenneth, Hoerauf, Achim, Altmeyer, Ralf and Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 (2014) 'Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis'. International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Issue 3, pp. 278-286.

Kay, Katherine and Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X (2011) 'Development, evaluation and application of an in silico model for antimalarial drug treatment and failure'. Antimicrobial Agents and Chemotherapy, Vol 55, Issue 7, pp. 3380-3392.

Klein, Kerenaftali, Aarons, Leon, terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617, Nosten, Francois, White, Nick J., Edstein, Michael D. and Teja-Isavadharm, Paktiya (2012) 'Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria'. Journal of Pharmacy and Pharmacology, Vol 64, Issue 11, pp. 1603-1613.

Kongkathip, Ngampong, Pradidphol, Narathip, Hasitapan, Komkrit, Grigg, Ronald, Kao, Wei-Chun, Hunte, Carola, Fisher, Nicholas, Warman, Ashley, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Kongsaeree, Palangpon, Chuawong, Pitak and Kongkathip, Boonsong (2010) 'Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents.'. Journal of medicinal chemistry, Vol 53, Issue 3, pp. 1211-1221.

Lucumi, Edinson, Darling, Claire, Jo, Hyunil, Napper, Andrew D., Chandramohanadas, Rajesh, Fisher, Nicholas, Shone, Alison, Jing, Huiyan, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, DeGrado, William F, Diamond, Scott L and Greenbaum, Doron C (2010) 'Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.'. Antimicrobial Agents and Chemotherapy, Vol 54, Issue 9, pp. 3597-3604.

Madanitsa, Mwayi, Kalilani, Linda, Mwapasa, Victor, vanEijk, Anna ORCID: https://orcid.org/0000-0003-1635-1289, Khairallah, Carole, Ali, Doreen, Pace, Cheryl, Smedley, James, Thwai, Kyaw-Lay, Levitt, Brandt, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Kang-ombe, Arthur, Faragher, Brian, Taylor, Steve M., Meshnick, Steve and terKuile, Feiko ORCID: https://orcid.org/0000-0003-3663-5617 (2016) 'Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial'. PLoS Medicine, Vol 13, Issue 9, e1002124.

Mekhaiel, David, Czajkowsky, Daniel M, Andersen, Jan Terje, Shi, Jianguo, El-Faham, Marwa, Doenhoff, Michael, McIntosh, Richard S, Sandlie, Inger, He, Jianfeng, Hu, Jun, Shao, Zhifeng and Pleass, Richard ORCID: https://orcid.org/0000-0001-7438-8296 (2011) 'Polymeric human Fc-fusion proteins with modified effector functions.'. Scientific reports, Vol 1, p. 124.

Miller, A. K., Bandyopadhyay, N., Wootton, D. G., Duparc, S., Kirby, P. L., Winstanley, P. A. and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2009) 'Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria'. European Journal of Clinical Pharmacology, Vol 65, Issue 10, pp. 977-987.

Mohammed, K. A., Haji, H. J., Gabrielli, A. F., Mubila, L., Biswas, G., Chitsulo, L., Bradley, M. H., Engels, D., Savioli, L. and Molyneux, David ORCID: https://orcid.org/0000-0001-8537-7947 (2008) 'Triple Co-Administration of Ivermectin, Albendazole and Praziquantel in Zanzibar: A Safety Study'. PLoS Neglected Tropical Diseases, Vol 2, Issue 1, e171.

Molyneux, David ORCID: https://orcid.org/0000-0001-8537-7947, Ndung'u, Joseph and Maudlin, Ian (2010) 'Controlling sleeping sickness--"when will they ever learn?".'. PLoS Neglected Tropical Diseases, Vol 4, Issue 5, e609.

Nduati, E., Hunt, S., Kamau, E. M. and Nzila, Alexis (2005) '2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials'. Antimicrobial Agents and Chemotherapy, Vol 49, Issue 9, pp. 3652-3657.

O'Neill, P. M., Mukhtar, A., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Bickley, J. F., Davies, Jill, Bachi, M. D. and Stocks, Paul A. (2004) 'Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore [Letter]'. Organic Letters, Vol 6, Issue 18, pp. 3035-3038.

O'Neill, Paul M., Hindley, Stephen, Pugh, Matthew D., Davies, Jill, Bray, Patrick, Park, B. Kevin, Kapu, Dauda S., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Stocks, Paul A. (2003) 'Co(thd)(2): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes'. Tetrahedron Letters, Vol 44, Issue 44, pp. 8135-8138.

O'Neill, Paul M., Shone, Alison, Stanford, Deborah, Nixon, Gemma, Asadollahy, Eghbaleh, Park, B. Kevin, Maggs, James L., Roberts, Phil, Stocks, Paul A., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick, Davies, Jill, Berry, Neil, Hall, Charlotte, Rimmer, Karen, Winstanley, Peter A., Hindley, Stephen, Bambal, Ramesh B., Davis, Charles B., Bates, Martin, Gresham, Stephanie L., Brigandi, Richard A., Gomez-de-las-Heras, Federico M., Gargallo, Domingo V., Parapini, Silvia, Vivas, Livia, Lander, Hollie, Taramelli, Donatella and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2009) 'Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compound for N-tert-Butyl Isoquine'. Journal of Medicinal Chemistry, Vol 52, Issue 7, pp. 1828-1844.

Richier, E., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Wein, S., Boudou, F., Bray, Patrick, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Precigout, E., Calas, M., Dubremetz, J. F. and Vial, H. J. (2006) 'Potent antihematozoan activity of novel bisthiazolium drug T16: Evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp.'. Antimicrobial Agents and Chemotherapy, Vol 50, Issue 10, pp. 3381-3388.

Rogers, Matthew E., Kropf, P., Choi, B. S., Dillon, Rod, Podinovskaia, M., Bates, Paul and Müller, I. (2009) 'Proteophosophoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host macrophages to promote parasite survival'. PLoS Pathogens, Vol 5, Issue 8, e1000555.

Slatko, Barton E., Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Foster, Jeremy M. (2010) 'The Wolbachia endosymbiont as an anti-filarial nematode target.'. Symbiosis (Philadelphia, Pa.), Vol 51, Issue 1, pp. 55-65.

Sloan, D. J., Dedicoat, Martin and Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200 (2009) 'Treatment of cryptococcal meningitis in resource limited settings'. Current Opinion in Infectious Diseases, Vol 22, Issue 5, pp. 455-463.

Stocks, Paul A., Bray, Patrick, Barton, V. E., Al-Helal, Mohammed, Jones, M., Araujo, N. C., Gibbons, P., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Hughes, Ruth, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Davies, Jill, Amewu, R., Mercer, A. E., Ellis, G. and O'Neill, P. M. (2007) 'Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs'. Angewandte Chemie-International Edition, Vol 46, Issue 33, pp. 6278-6283.

Suputtamongkol, Y., Kungpanichkul, N., Silpasakorn, S. and Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791 (2008) 'Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis'. International Journal of Antimicrobial Agents, Vol 31, Issue 1, pp. 46-49.

Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Boulton, Ian C (2013) 'CRIMALDDI: a prioritized research agenda to expedite the discovery of new anti-malarial drugs'. Malaria Journal, Vol 12, : 395.

Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Jones, K. (2002) 'Biguanide-atovaquone synergy against Plasmodium falciparum in vitro'. Antimicrobial Agents and Chemotherapy, Vol 46, Issue 8, pp. 2700-2703.