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Conditional power analysis of the DEBUT trial

Wang, Yang, Chen, Tao ORCID:, Li, Sidong, Zhao, Yanyan and Li, Wei (2020) 'Conditional power analysis of the DEBUT trial'. Lancet, Vol 395, Issue 10224, p. 560.

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Tuomas Rissanen and colleagues reported a statistically significantly reduced incidence of major adverse cardiac events in patients with de-novo coronary artery lesions at a high risk of bleeding treated with a drug-coated balloon compared with those treated with a bare-metal stent. In this study, the absolute difference in major adverse cardiac events at 9 months was reported as −13·2 percentage points (95% CI −6·2 to −21·1). Therefore, the authors claimed that percutaneous coronary intervention with drug-coated balloon was superior to bare-metal stent in patients at risk of bleeding. However, we believe that these results should be interpreted with caution.

Item Type: Article
Subjects: W General Medicine. Health Professions > W 20.5 Biomedical research
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
WB Practice of Medicine > Therapeutics > WB 305 Instructions or non-drug prescriptions for devices or therapy (General)
WG Cardiovascular System > WG 20 Research (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Christine Bradbury
Date Deposited: 24 Feb 2020 13:05
Last Modified: 22 Feb 2021 02:02


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