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Endomyocardial Fibrosis: an Update After 70 Years

Mocumbi, Ana, Stothard, Russell ORCID:, Correia-de-Sá, Paulo and Yacoub, Magdi (2019) 'Endomyocardial Fibrosis: an Update After 70 Years'. Current Cardiology Reports, Vol 21, e148.

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Purpose of Review
This review aims at highlighting the need to better understand the pathogenesis and natural history of endomyocardial fibrosis when set against its changing endemicity and disease burden, improvements in diagnosis, and new options for clinical management.

Recent Findings
Progress in imaging diagnostic techniques and availability of new targets for drug and surgical treatment of heart failure are contributing to earlier diagnosis and may lead to improvement in patient survival.

Endomyocardial fibrosis was first described in Uganda by Davies more than 70 years ago (1948). Despite its poor prognosis, the etiology of this neglected tropical restrictive cardiomyopathy still remains enigmatic nowadays. Our review reflects on the journey of scientific discovery and construction of the current guiding concepts on this mysterious and fascinating condition, bringing to light the contemporary knowledge acquired over these years. Here we describe novel tools for diagnosis, give an overview of the improvement in clinical management, and finally, suggest research themes that can help improve patient outcomes focusing (whenever possible) on novel players coming into action.

Item Type: Article
Subjects: WG Cardiovascular System > WG 100 General works
WG Cardiovascular System > Heart. Heart Diseases > WG 200 General works
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
Depositing User: Cathy Waldron
Date Deposited: 25 Nov 2019 12:53
Last Modified: 22 Nov 2020 02:02


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