Tools
Tools
Band, Gavin, Le, Quang Si, Clarke, Geraldine M., Kivinen, Katja, Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Leffler, Ellen M., Jallow, Muminatou, Conway, David J., Sisay-Joof, Fatoumatta, Sirugo, Giorgio, d’Alessandro, Umberto, Toure, Ousmane B., Thera, Mahamadou A., Konate, Salimata, Sissoko, Sibiri, Mangano, Valentina D., Bougouma, Edith C., Sirima, Sodiomon B., Amenga-Etego, Lucas N., Ghansah, Anita K., Hodgson, Abraham V. O., Wilson, Michael D., Enimil, Anthony, Ansong, Daniel, Evans, Jennifer, Ademola, Subulade A., Apinjoh, Tobias O., Ndila, Carolyne M., Manjurano, Alphaxard, Drakeley, Chris, Reyburn, Hugh, Phu, Nguyen Hoan, Ngoc Quyen, Nguyen Thi, Thai, Cao Quang, Hien, Tran Tinh, Teo, Yik Ying, Manning, Laurens, Laman, Moses, Michon, Pascal, Karunajeewa, Harin, Siba, Peter, Allen, Steve 
ORCID: https://orcid.org/0000-0001-6675-249X, Allen, Angela, Bahlo, Melanie, Davis, Timothy M. E., Cornelius, Victoria, Shelton, Jennifer, Spencer, Chris C.A., Busby, George B.J., Kerasidou, Angeliki, Drury, Eleanor, Stalker, Jim, Dilthey, Alexander, Mentzer, Alexander J., McVean, Gil, Bojang, Kalifa A., Doumbo, Ogobara, Modiano, David, Koram, Kwadwo A., Agbenyega, Tsiri, Amodu, Olukemi K., Achidi, Eric, Williams, Thomas N., Marsh, Kevin, Riley, Eleanor M., Molyneux, Malcolm, Taylor, Terrie, Dunstan, Sarah J., Farrar, Jeremy, Mueller, Ivo, Rockett, Kirk A. and Kwiatkowski, Dominic P.
(2019)
'Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania'. Nature Communications, Vol 10, Issue 5732.
|
Text
2019-07-02 MalariaGEN GWAS Supplementary1.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (29MB) | Preview |
|
|
Text
Figure 01 - data and structure.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (898kB) | Preview |
|
|
Text
Figure 02 - manhattan.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (273kB) | Preview |
|
|
Text
Figure 03 - rs6241876.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (459kB) | Preview |
|
|
Text
Figure 04 - patterns of risk v6.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (9kB) | Preview |
|
|
Text
Figure 05 - ATP2B4.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (2MB) | Preview |
|
|
Text
Figure 06 - HLA.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (2MB) | Preview |
|
![[img]](https://archive.lstmed.ac.uk/style/images/fileicons/other.png) |
Spreadsheet
Supplementary tables.xlsx - Supplemental Material Available under License Creative Commons Attribution. Download (857kB) |
|
|
Text
535898v2.full.pdf - Accepted Version Available under License Creative Commons Attribution. Download (26MB) | Preview |
Abstract
We conducted a genome-wide association study of host resistance to severe Plasmodium falciparum malaria in over 17,000 individuals from 11 malaria- endemic countries, undertaking a wide ranging analysis which identifies five replicable associations with genome-wide levels of evidence. Our findings include a newly implicated variant on chromosome 6 associated with risk of cerebral malaria, and the discovery of an erythroid-specific transcription start site underlying the association in ATP2B4. Previously reported HLA associations cannot be replicated in this dataset. We estimate substantial heritability of severe malaria (h2 ~ 23%), of which around 10% is explained by the currently identified associations. Our dataset will provide a major building block for future research on the genetic determinants of disease in these diverse human populations.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 460 Genomics. Proteomics WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 755 Epidemiology |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41467-019-13480-z |
| Depositing User: | Marie Hatton |
| Date Deposited: | 06 Jan 2020 16:49 |
| Last Modified: | 06 Jan 2020 16:49 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/13321 |
Statistics
Actions (login required)
 |
Edit Item |