Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx

Hales, Caz, Jochems, Simon P, Robinson, Rachel, SolorzanoGonzalez, Carl, Carniel, Biatriz, Pojar, Sherin ORCID: https://orcid.org/0000-0002-7746-3279, Reiné, Jesús, German, Esther, Nikolaou, Elissavet, Mitsi, Elena, Hyder-Wright, Angela, Hill, Helen, Adler, Hugh ORCID: https://orcid.org/0000-0003-4437-2298, Connor, Victoria, Zaidi, Seher, Lowe, Catherine, Fan, Xiaojing, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611 and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2020) 'Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx'. Vaccine, Vol 38, Issue 10, pp. 2298-2306.

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Abstract

Background

Nasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality during influenza epidemics. Increased bacterial load and impaired immune responses to pneumococcus caused by influenza play a role in this increased susceptibility. Using an Experimental Human Challenge Model and influenza vaccines, we examined symptoms experienced by healthy adults during nasal co-infection with S. pneumoniae and live attenuated influenza virus.
Methods

Randomised, blinded administration of Live Attenuated Influenza Vaccine (LAIV) or Tetravalent Inactivated Influenza Vaccine (TIV) either preceded bacterial inoculation or followed it, separated by a 3-day interval. The presence and density of S. pneumoniae was determined from nasal washes. Participants completed a symptom questionnaire from the first intervention until 6 days post second intervention.
Results

The timing and type of influ

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 202 Pneumonia (General or not elsewhere classified) WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza WV Otolaryngology > Pharyngeal Region > WV 400 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.vaccine.2020.01.070
Depositing User:	Catherine Molloy
Date Deposited:	20 Feb 2020 16:51
Last Modified:	03 Dec 2024 09:00
URI:	https://archive.lstmed.ac.uk/id/eprint/13723

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