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RNA editing: an overlooked source of fine-scale adaptation in insect vectors?

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Grau-Bové, Xavier and Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388 (2020) 'RNA editing: an overlooked source of fine-scale adaptation in insect vectors?'. Current Opinion in Insect Science, Vol 40, pp. 48-55.

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Abstract

RNA editing is a source of molecular diversity that regulates the functional repertoire of animal transcriptomes. Multiple studies in Drosophila have revealed that conserved editing events can be a 10 source of evolutionary ad aptations, and there is a solid body of evidence linking editing and the fine tuning of neural genes, which are often targeted by insecticides used in vector control. Yet, 12 despite these suggestive connections, genome wide analyses of editing in insect vect ors are conspicuously lacking. Future advances will require complementing the growing wealth of vector 14 genomes with targeted transcriptome analyses. Here, we review recent investigations of the genetic
footprints of adaptive RNA editing in insects and prov ide an overview of new methodologies 16 applicable to studies of RNA editing in insect vectors.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 470 Genetic structures
QU Biochemistry > Genetics > QU 475 Genetic processes
QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.7 RNA
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.cois.2020.05.004
Depositing User: Luciene Salas Jennings
Date Deposited: 26 May 2020 13:58
Last Modified: 12 Aug 2020 10:19
URI: https://archive.lstmed.ac.uk/id/eprint/14487

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