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Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Jackson, J. A., Turner, Joseph ORCID:, Kamal, M., Wright, V., Bickle, Q., Else, K. J., Ramsan, M. and Bradley, J. E. (2006) 'Gastrointestinal nematode infection is associated with variation in innate immune responsiveness'. Microbes and Infection, Vol 8, Issue 2, pp. 487-492.

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Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

Item Type: Article
Uncontrolled Keywords: monocyte innate immunity human nematodiasis tlr4 tlr2 tnf-alpha il-10 tgf-beta necrosis-factor-alpha plasmodium-falciparum malaria vaccine cvd 103-hgr hepatitis-c virus ascaris-lumbricoides dendritic cells host-defense cytokine tlr4 mice
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QX Parasitology > Helminths. Annelida > QX 203 Nematoda
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 850 Nematode infections (General)
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):
Depositing User: Martin Chapman
Date Deposited: 26 May 2011 15:39
Last Modified: 15 Sep 2019 11:19


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