Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance

Rodríguez-Baño, Jesús, Rossolini, Gian Maria, Schultsz, Constance, Tacconelli, Evelina, Murthy, Srinivas, Ohmagari, Norio, Holmes, Alison, Bachmann, Till, Goossens, Herman, Canton, Rafael, Roberts, Adam P ORCID: https://orcid.org/0000-0002-0760-3088, Henriques-Normark, Birgitta, Clancy, Cornelius J., Huttner, Benedikt, Fagerstedt, Patriq, Lahiri, Shawon, Kaushic, Charu, Hoffman, Steven J., Warren, Margo, Zoubiane, Ghada, Essack, Sabiha, Laxminarayan, Ramanan and Plant, Laura (2021) 'Key considerations on the potential impacts of the COVID-19 pandemic on antimicrobial resistance research and surveillance'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Issue trab048.

Text ARoberts AMR COVID Manuscript_TRSTMH_revised.docx - Accepted Version Available under License Creative Commons Attribution Non-commercial. Download (171kB)

Abstract

Antibiotic use in SARS-CoV-2 patients in the COVID-19 pandemic exceeded the incidence of bacterial co-infections and secondary infections, suggesting inappropriate and excessive prescribing. Even in settings with established antimicrobial stewardship programmes, there were weaknesses exposed regarding appropriate antibiotic use in the context of the pandemic. Moreover, antimicrobial resistance (AMR) surveillance and antimicrobial stewardship (AMS) have been deprioritised with diversion of health system resources to the pandemic response. This experience highlights deficiencies in AMR containment and mitigation strategies that require urgent attention from clinical and scientific communities. These include the need to implement diagnostic stewardship to assess the global incidence of co-infections and secondary infections in COVID-19 patients including those by multi-drug resistant pathogens, identify patients most likely to benefit from antibiotic treatment, and, identify when antibiotics can be safely withheld, de-escalated or discontinued. Long-term global surveillance of clinical and societal antibiotic use and resistance trends is required to prepare for subsequent changes in AMR epidemiology, while ensuring uninterrupted supply chains and preventing drug shortages and stock outs. These interventions present implementation challenges in resource-constrained settings, making a case for implementation research on AMR. Knowledge and support for these practices will come from internationally coordinated, targeted research on AMR, supporting the preparation for future challenges from emerging AMR in the context of the current COVID-19 pandemic or future pandemics.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. WA Public Health > WA 105 Epidemiology WB Practice of Medicine > Therapeutics > WB 330 Drug therapy WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1093/trstmh/trab048
Depositing User:	Cathy Waldron
Date Deposited:	29 Mar 2021 08:47
Last Modified:	29 Mar 2021 08:47
URI:	https://archive.lstmed.ac.uk/id/eprint/17166

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