Small molecule drug discovery for neglected tropical snakebite

Clare, Rachel ORCID: https://orcid.org/0000-0002-3945-0530, Hall, Steven, Patel, Rohit and Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719 (2021) 'Small molecule drug discovery for neglected tropical snakebite'. Trends in Pharmacological Sciences, Vol 42, Issue 5, pp. 340-353.

Text Clare et al 2021_Small molecule drug discovery_Trends_March-21.docx - Accepted Version Download (14MB)

Abstract

Snakebite envenoming is responsible for as many as 138,000 deaths annually, making it the world’s most lethal neglected tropical disease (NTD). There is an urgent need to improve snakebite treatment, which currently relies on outdated and poorly tolerated biologic antivenoms that are often weakly efficacious, must be given intravenously in a healthcare setting, and are expensive to those who need them the most. Herein we describe the challenges associated with the discovery and development of new snakebite treatments and detail the great potential of venom toxin-inhibiting small molecule drugs. We finish by highlighting successful enabling strategies applied to other NTDs that could be exploited to facilitate the development of next-generation, small molecule-based, snakebite treatments.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 630 Toxins. Antitoxins WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 400 General works WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.tips.2021.02.005
Depositing User:	Mary Creegan
Date Deposited:	26 Mar 2021 11:48
Last Modified:	24 Mar 2022 02:02
URI:	https://archive.lstmed.ac.uk/id/eprint/17271

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