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Perez, Freddy, Caceres, Diego H, Ford, Nathan, Ravasi, Giovanni, Gomez, Beatriz L, Pasqualotto, Alessandro C, Hine, Paul, Adenis, Antoine A, Nacher, Mathieu, Chiller, Tom and Badley, John (2021) 'Summary of Guidelines for Managing Histoplasmosis among People Living with HIV'. Journal Fungi, Vol 7, Issue 2, p. 134.
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Abstract
Abstract: Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population.
In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by
a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral
therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and
tuberculosis (TB), treatment of TB should be initiated according to the World Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy
guidance for the care of PLHIV are required.
| Item Type: | Article |
|---|---|
| Additional Information: | This article belongs to the Special Issue Histoplasma and Histoplasmosis 2020 |
| Subjects: | WC Communicable Diseases > Mycoses > WC 465 Histoplasmosis WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications WF Respiratory System > Lungs > WF 600 Lungs |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.3390/jof7020134 |
| Depositing User: | Christianne Esparza |
| Date Deposited: | 22 Apr 2021 16:41 |
| Last Modified: | 22 Apr 2021 16:41 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/17646 |
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