The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

Cansado-Utrilla, Cintia, Zhao, Serena Y., McCall, Philip ORCID: https://orcid.org/0000-0002-0007-3985, Coon, Kerri L. and Hughes, Grant ORCID: https://orcid.org/0000-0002-7567-7185 (2021) 'The microbiome and mosquito vectorial capacity: rich potential for discovery and translation'. Microbiome, Vol 9, Issue 111.

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Abstract

Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence, and the pathogen extrinsic incubation period all influence pathogen transmission. Recent studies also indicate that mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps regarding mosquito–microbe interactions that need to be addressed in order to exploit them efficiently. Here, we review current evidence of impacts of the microbiome on aspects of vectorial capacity, and we highlight likely opportunities for novel vector control strategies and areas where further studies are required.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole. QX Parasitology > QX 4 General works QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1186/s40168-021-01073-2
Depositing User:	Samantha Sheldrake
Date Deposited:	03 Jun 2021 10:04
Last Modified:	03 Jun 2021 10:04
URI:	https://archive.lstmed.ac.uk/id/eprint/17978

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