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Thomson-Luque, Richard, Votborg-Novél, Lasse, Ndovie, Wanangwa, Andrade, Carolina M., Niangaly, Moussa, Attipa, Charalampos, Lima, Nathalia F., Coulibaly, Drissa, Doumtabe, Didier, Guindo, Bouréima, Tangara, Bourama, Maiga, Fayçal, Kone, Abdoulaye Kassoum, Traore, Karim, Kayentao, Kassoum, Ongoiba, Aissata, Doumbo, Safiatou, Thera, Mahamadou A., Traoré, Boubacar, Seydel, Karl, Osório, Nuno S. and Portugal, Silvia (2021) 'Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes'. Nature Communications, Vol 12, Issue 4711.
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Abstract
Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falciparum’s tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental cycle (IDC) to publicly available transcriptomes of parasites obtained from malaria cases of differing clinical severity across multiple studies. Our analysis shows that within each IDC, the circulation time of infected erythrocytes without sequestering to endothelial cells decreases with increasing parasitaemia or disease severity. Accordingly, we find that the size of circulating infected erythrocytes is inversely related to parasite density and disease severity. We propose that enhanced dhesiveness of infected erythrocytes leads to a rapid increase in parasite burden, promoting higher parasitaemia and increased disease severity.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole. WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WH Hemic and Lymphatic Systems > WH 20 Research (General) |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/s41467-021-25062-z |
| Depositing User: | Cathy Waldron |
| Date Deposited: | 11 Aug 2021 13:01 |
| Last Modified: | 11 Aug 2021 13:01 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/18614 |
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