LSTM Home > LSTM Research > LSTM Online Archive

A novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 86

Cerdeira, Louise, Nakamura-Silva, Rafael, Oliveira-Silva, Mariana, Sano, Elder, Esposito, Fernanda, Fuga, Bruna, Moura, Quézia, Miranda, Carlos Eduardo Saraiva, Wyres, Kelly, Lincopan, Nilton and Pitondo-Silva, André (2021) 'A novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 86'. Pathogens and Disease, Vol 79, Issue 8.

[img]
Preview
Text
ftab047.pdf - Accepted Version

Download (648kB) | Preview

Abstract

Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piauí, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype, and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 460 Genomics. Proteomics
QU Biochemistry > Genetics > QU 470 Genetic structures
QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping
QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1093/femspd/ftab047
Depositing User: Stacy Murtagh
Date Deposited: 07 Oct 2021 16:16
Last Modified: 22 Sep 2022 01:02
URI: https://archive.lstmed.ac.uk/id/eprint/19120

Statistics

View details

Actions (login required)

Edit Item Edit Item