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Cerdeira, Louise, Nakamura-Silva, Rafael, Oliveira-Silva, Mariana, Sano, Elder, Esposito, Fernanda, Fuga, Bruna, Moura, Quézia, Miranda, Carlos Eduardo Saraiva, Wyres, Kelly, Lincopan, Nilton and Pitondo-Silva, André (2021) 'A novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 86'. Pathogens and Disease, Vol 79, Issue 8.
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Abstract
Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piauí, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype, and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil.
| Item Type: | Article |
|---|---|
| Subjects: | QU Biochemistry > Genetics > QU 460 Genomics. Proteomics QU Biochemistry > Genetics > QU 470 Genetic structures QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1093/femspd/ftab047 |
| Depositing User: | Stacy Murtagh |
| Date Deposited: | 07 Oct 2021 16:16 |
| Last Modified: | 22 Sep 2022 01:02 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/19120 |
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