Advances in Preclinical Platforms of Loa loa for Filarial Neglected Tropical Disease Drug and Diagnostics Research

Wanji, Samuel, Chunda, Valerine Chawa, Fombad, Fanny Fri, Njouendou, Abdel Jélil, Gandjui, Narcisse Victor T., Ritter, Manuel, Enyong, Peter A., Mackenzie, Charles, Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275, Hoerauf, Achim and Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476 (2021) 'Advances in Preclinical Platforms of Loa loa for Filarial Neglected Tropical Disease Drug and Diagnostics Research'. Frontiers in Tropical Diseases, Vol 2, p. 778724.

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Abstract

The tropical disease, loiasis, caused by the filarial parasite, Loa loa, has gained prominence in global public health as a cause of excess mortality and a barrier to the elimination of the related prioritized neglected tropical diseases (NTDs), lymphatic filariasis and onchocerciasis, within Central Africa. There are no effective drug cures or vaccines available to treat loiasis safely. Here we review recent advances in loiasis preclinical platform technologies, including novel in vitro culturing systems, animal models and innovations in experimental infections of the L. loa vector, Chrysops, that have facilitated access to all L. loa filarial life-cycle stages. We detail applications of these new model systems in anti-filarial drug screening, diagnostic development, immunology, and pathophysiology research. Finally, we provide an overview of how loiasis preclinical platforms may be further utilized in translational medicine applications to support the development of much needed new interventions against filarial NTDs.

Item Type:	Article
Additional Information:	Test of the 'Additional Information' field. Please ignore.
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 695 Parasitic diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 850 Nematode infections (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General) WW Ophthalmology > Diseases. Color Perception > WW 140 Eye diseases
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.3389/fitd.2021.778724
Depositing User:	Cathy Waldron
Date Deposited:	08 Nov 2021 10:22
Last Modified:	19 Nov 2024 16:12
URI:	https://archive.lstmed.ac.uk/id/eprint/19370

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