LSTM Home > LSTM Research > LSTM Online Archive

Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study

Allen, Stephen ORCID:, Belnour, Salma, Renji, Elizabeth, Carter, Bernie, Bray, Lucy, Allen, Angie, Jones, Emma, Urban, Britta ORCID:, Moule, Sarah, Wang, Duolao ORCID: and Playford, Raymond J. (2022) 'Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn’s Disease; A Feasibility Study'. Nutrients, Vol 14, Issue 21, p. 4598.

nutrients-14-04598-v2.pdf - Published Version
Available under License Creative Commons Attribution.

Download (935kB) | Preview


Bovine colostrum (BC) has anti-inflammatory, anti-infective, growth and intestinal repair factors that may be beneficial in Crohn’s disease (CD). We assessed whether daily BC for up to 3 months was acceptable to children and young people (CYP) with CD in remission or of mild/moderate severity. CYP were randomised to receive either BC or matching placebo milk daily for 6 weeks (blinded phase); all received BC for the following 6 weeks (open phase). In 23 CYP, median (inter-quartile range) age was 15.2 (13.9–16.1) years and 9 (39.1%) were girls. A similar proportion of CYP in the BC and placebo arms completed the blinded phase (8/12, 75.0% and 9/11, 81.8% respectively). Twelve (70.6%) CYP completed the open phase with 7 (58.3%) tolerating BC for 3 months. Diaries in weeks 2, 6 and 12 revealed that most CYP took BC every day (5/7, 71.4%; 5/8, 62,5% and 6/11, 54.5% respectively). In interviews, opinions were divided as to preference of BC over the placebo milk and some preferred BC over other nutritional supplements. Symptoms, clinical and laboratory variables and quality of life were similar in the two arms. BC may be an acceptable nutritional supplement for daily, longer-term use in CYP with CD

Item Type: Article
Subjects: WI Digestive System > WI 140 Diseases (General)
WI Digestive System > WI 20 Research (General)
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 115 Nutritional requirements. Nutrition disorders
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Julie Franco
Date Deposited: 03 Nov 2022 16:29
Last Modified: 03 Nov 2022 16:29


View details

Actions (login required)

Edit Item Edit Item