Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

Nabwera, Helen, Espinoza, Josh L., Worwui, Archibald, Betts, Modupeh, Okoi, Catherine, Sesay, Abdul K., Bancroft, Rowan, Agbla, Schadrac C., Jarju, Sheikh, Bradbury, Richard S., Colley, Mariama, Jallow, Amadou T., Liu, Jie, Houpt, Eric R, Prentice, Andrew M., Antonio, Martin, Bernstein, Robin M, Dupont, Christopher L. and Kwambana-Adams, Brenda A. (2021) 'Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children'. EBioMedicine, Vol 73, e103644.

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Abstract

Background

The specific roles that gut microbiota, known pathogens, and host energy-regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition (marasmus SAM) and moderate acute malnutrition (MAM) during outpatient nutritional rehabilitation are yet to be explored.
Methods

We applied an ensemble of sample-specific (intra- and inter-modality) association networks to gain deeper insights into the pathogenesis of acute malnutrition and its severity among children under 5 years of age in rural Gambia, where marasmus SAM is most prevalent.

Findings

Children with marasmus SAM have distinct microbiome characteristics and biologically-relevant multimodal biomarkers not observed among children with moderate acute malnutrition. Marasmus SAM was characterized by lower microbial richness and biomass, significant enrichments in Enterobacteriaceae, altered interactions between specific Enterobacteriaceae and key energy regulating hormones and their receptors.

Interpretation

Our findings suggest that marasmus SAM is characterized by the collapse of a complex system with nested interactions and key associations between the gut microbiome, enteric pathogens, and energy regulating hormones. Further exploration of these systems will help inform innovative preventive and therapeutic interventions.

Item Type:	Article
Subjects:	QU Biochemistry > Vitamins > QU 145 Nutrition. Nutritional requirements QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole. WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 105 Deficiency diseases WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 115 Nutritional requirements. Nutrition disorders
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.ebiom.2021.103644
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	19 Jan 2023 13:24
Last Modified:	16 Jun 2023 08:19
URI:	https://archive.lstmed.ac.uk/id/eprint/21806

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