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A global core outcome measurement set for snakebite clinical trials.

Abouyannis, Michael ORCID:, Esmail, Hanif, Hamaluba, Mainga, Ngama, Mwanajuma, Mwangudzah, Hope, Mumba, Noni, Yeri, Betty K, Mwalukore, Salim, Alphan, Hassan J, Aggarwal, Dinesh, Alcoba, Gabriel, Cammack, Nick, Chippaux, Jean-Philippe, Coldiron, Matthew E, Gutiérrez, José M, Habib, Abdulrazaq G, Harrison, Robert, Isbister, Geoffrey K, Lavonas, Eric J, Martins, Diogo, Ribeiro, Isabela, Watson, James A, Williams, David J, Casewell, Nicholas ORCID:, Walker, Sarah A and Lalloo, David ORCID: (2023) 'A global core outcome measurement set for snakebite clinical trials.'. Lancet Global Health, Vol 11, Issue 2, e296-e300.

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Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials-mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.

Item Type: Article
Subjects: QV Pharmacology > Toxicology > General Toxicology > QV 601 Antidotes and other therapeutic measures
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 24 Jan 2023 15:22
Last Modified: 24 Jan 2023 15:22


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