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Items where Subject is "QV Pharmacology > Toxicology > General Toxicology > QV 601 Antidotes and other therapeutic measures"

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Number of items at this level: 34.


Abouyannis, Michael ORCID: (2024) Development of a repurposed orally available small molecule snakebite therapeutic: clinical need, safety, pharmacokinetics, and proposed methods to assess efficacy, Thesis (Doctoral), Liverpool School of Tropical Medicine.

Abouyannis, Michael ORCID:, Esmail, Hanif, Hamaluba, Mainga, Ngama, Mwanajuma, Mwangudzah, Hope, Mumba, Noni, Yeri, Betty K, Mwalukore, Salim, Alphan, Hassan J, Aggarwal, Dinesh, Alcoba, Gabriel, Cammack, Nick, Chippaux, Jean-Philippe, Coldiron, Matthew E, Gutiérrez, José M, Habib, Abdulrazaq G, Harrison, Robert, Isbister, Geoffrey K, Lavonas, Eric J, Martins, Diogo, Ribeiro, Isabela, Watson, James A, Williams, David J, Casewell, Nicholas ORCID:, Walker, Sarah A and Lalloo, David ORCID: (2023) 'A global core outcome measurement set for snakebite clinical trials.'. Lancet Global Health, Vol 11, Issue 2, e296-e300.

Ainsworth, Stuart ORCID:, Petras, Daniel, Engmark, Mikael, Sussmuth, Roderich, Whiteley, Gareth, Albulescu, Laura-Oana ORCID:, Kazandijan, Taline D, Wagstaff, Simon ORCID:, Rowley, Paul, Wüster, Wolfgang, Dorrestein, Pieter C., Arias, Ana Silvia, Gutiérrez, José M., Harrison, Robert, Casewell, Nicholas ORCID: and Calvete, Juan J (2018) 'The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.'. Journal of Proteomics, Vol 192, pp. 173-189.

Alsolaiss, Jaffar, Alomran, Nessrin ORCID:, Hawkins, Laura and Casewell, Nicholas ORCID: (2022) 'Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms'. Toxins, Vol 15, Issue 1, e1.


Bartlett, Keirah, Hall, Steven, Rasmussen, Sean A., Crittenden, Edouard, Dawson, Charlotte, Albulescu, Laura-Oana ORCID:, Laprade, William, Harrison, Robert, Saviola, Anthony J., Modahl, Cassandra, Jenkins, Timothy P., Wilkinson, Mark ORCID:, Gutiérrez, José María and Casewell, Nicholas ORCID: (2024) 'Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib'. Proceedings of the National Academy of Sciences of the United States of America, Vol 121, Issue 19, e2315597121.

Bittenbinder, Mátyás A., Wachtel, Eric, Pereira, Daniel Da Costa, Slagboom, Julien, Casewell, Nicholas ORCID:, Jennings, Paul, Kool, Jeroen and Vonk, Freek J. (2024) 'Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation'. Toxicon: X, Vol 22, p. 100197.


Caron, E. J., Manock, S. R., Maudlin, J., Koleski, J., Theakston, R.David G., Warrell, D. A. and Smalligan, R. D. (2009) 'Apparent marked reduction in early antivenom reactions compared to historical controls: Was it prophylaxis or method of administration?'. Toxicon, Vol 54, Issue 6, pp. 779-783.

Casewell, Nicholas ORCID:, Al-Abdulla, Ibrahim, Smith, David, Coxon, Ruth and Landon, John (2014) 'Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb.'. Toxins, Vol 6, Issue 8, pp. 2471-2482.


Dawson, Charlotte (2021) Development of a Novel Therapeutic for the Treatment of Snakebite Induced Necrosis in Sub-Saharan Africa, Thesis (Doctoral), Liverpool School of Tropical Medicine.

De Silva, H. A., Fonseka, M. M. D., Pathmeswaran, A., Ratnatilake, G. A., Alahakoon, D. G. S., Ranasinha, C. D., Gunatilake, S. B., Lalloo, David ORCID:, Aronson, J. K. and De Silva, H. J. (2003) 'Treatment of yellow oleander poisoning with multiple dose activated charcoal: a randomized controlled trial'. British Journal of Clinical Pharmacology, Vol 55, Issue 4, pp. 422-423.

de Silva, H. A., Fonseka, M. M. D., Pathmeswaran, A., Alahakone, D. G. S., Ratnatilake, G. A., Gunatilake, S. B., Ranasinha, C. D., Lalloo, David ORCID:, Aronson, J. K. and de Silva, H. J. (2003) 'Multiple-dose activated charcoal for treatment of yellow oleander poisoning: a single-blind, randomised, placebo-controlled trial'. Lancet, Vol 361, Issue 9373, pp. 1935-1938.

de Silva, H. A., Pathmeswaran, A., Lalloo, David ORCID:, de Silva, H. J. and Aronson, J. K. (2008) 'Multiple-dose activated charcoal in yellow oleander poisoning'. Lancet, Vol 371, Issue 9631, p. 2171.


Fahmi, Laila, Makran, Bouchra, Pla, Davinia, Sanz, Libia, Oukkache, Naoual, Lkhider, Mustapha, Harrison, Robert, Ghalim, Noreddine and Calvete, Juan J (2012) 'Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness.'. Journal of Proteomics, Vol 75, Issue 8, pp. 2442-53.


Gutiérrez, José María, Burnouf, Thierry, Harrison, Robert, Calvete, Juan J, Kuch, Ulrich, Warrell, David A and Williams,, David J (2014) 'A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming'. Bulletin of the World Health Organization, Vol 92, Issue 7, pp. 526-532.


Habib, A. G., Abubakar, S. B., Abubakar, I. S., Larnyang, S., Durfa, N., Nasidi, A., Yusuf, P. O., Garnvwa, J., Theakston, R.David G., Salako, L. and Warrell, D. A. (2008) 'Envenoming after carpet viper (Echis ocellatus) bite during pregnancy: timely use of effective antivenom improves maternal and foetal outcomes'. Tropical Medicine & International Health, Vol 13, Issue 9, pp. 1172-1175.

Hall, Steven, Crittenden, Edouard, Dawson, Charlotte, Bartlett, Keirah, Westhorpe, Adam, Albulescu, Laura-Oana ORCID: and Casewell, Nicholas ORCID: (2023) 'Drug combination therapies effectively inhibit the dermonecrotic activity of cytotoxic venoms from geographically diverse snake species in vivo' in British Pharmacological Society 2022, Tuesday 13th September.

Harrison, Robert, Oliver, J., Hasson, S.S., Bharati, K. and Theakston, R.David G. (2003) 'Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species'. Gene, Vol 315, pp. 95-102.

Harrison, Robert, Oluoch, George O., Ainsworth, Stuart ORCID:, Alsolaiss, Jaffer, Bolton, Fiona, Arias, Ana-Silvia, Gutiérrez, José-María, Rowley, Paul, Kalya, Stephen, Ozwara, Hastings and Casewell, Nicholas ORCID: (2017) 'Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa'. PLoS Neglected Tropical Diseases, Vol 11, Issue 10, e0005969.

Harrison, Robert, Hargreaves, Adam, Wagstaff, Simon ORCID:, Faragher, Brian and Lalloo, David ORCID: (2009) 'Snake Envenoming: A Disease of Poverty'. PLoS Neglected Tropical Diseases, Vol 3, Issue 12, e569.

Harrison, Robert, Wuster, W. and Theakston, R.David G. (2003) 'The conserved structure of snake venom toxins confers extensive immunological cross-reactivity to toxin-specific antibody'. Toxicon, Vol 41, Issue 4, pp. 441-449.

Harrison, Robert and Wernery, U. (2007) 'The unique properties of camelid IgG have potential to improve the treatment of snake bite'. Journal of Camel Practice and Research, Vol 14, Issue 1, pp. 15-16.

Hempel, Benjamin-Florian, Damm, Maik, Petras, Daniel, Kazandjian, Taline D., Szentiks, Claudia A., Fritsch, Guido, Nebrich, Grit, Casewell, Nicholas ORCID:, Klein, Oliver and Süssmuth, Roderich D. (2023) 'Spatial Venomics─Cobra Venom System Reveals Spatial Differentiation of Snake Toxins by Mass Spectrometry Imaging'. Journal of Proteome Research, Vol 22, Issue 1, pp. 26-35.

Howes, J.M., Theakston, R.David G. and Laing, Gavin (2005) 'Antigenic relationships and relative immunogenicities of isolated metalloproteinases from Echis ocellatus venom'. Toxicon, Vol 45, Issue 5, pp. 677-680.

Howes, J.M., Wilkinson, M. C., Theakston, R.David G. and Laing, Gavin (2003) 'The purification and partial characterisation of two novel metalloproteinases from the venom of the West African carpet viper, Echis ocellatus'. Toxicon, Vol 42, Issue 1, pp. 21-27.


Isbister, Geoffrey K., Maduwage, Kalana, Saiao, Ana, Buckley, Nicholas A., Jayamanne, Shaluka F., Seyed, Shahmy, Mohamed, Fahim, Chathuranga, Umesh, Alexandre, Mendes, Abeysinghe, Chandana, Karunathilake, Harinda, Gawarammana, Indika, Lalloo, David ORCID: and Janaka de Silva, H. (2015) 'Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites'. PLoS Neglected Tropical Diseases, Vol 9, Issue 7, e0003873.


Laing, Gavin, Harrison, Robert, Theakston, R.David G., Renjifo, J. M., Nasidi, A., Gutierrez, J. M. and Warrell, D. A. (2003) 'Polyspecific snake antivenom may help in antivenom crisis'. British Medical Journal (BMJ), Vol 326, Issue 7386, pp. 447-448.

Laing, Gavin, Yarleque, A., Marcelo, A., Rodriguez, E., Warrell, David A. and Theakston, R.David G. (2004) 'Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms'. Toxicon, Vol 44, Issue 1, pp. 103-106.


Maduwage, Kalana, Buckley, Nick A., Janaka de Silva, H., Lalloo, David ORCID: and Isbister, Geoffrey K. (2015) 'Snake antivenom for snake venom induced consumption coagulopathy'. Cochrane Database of Systematic Reviews, Vol 6, CD011428.

Menzies, Stefanie ORCID:, Clare, Rachel ORCID:, Xie, Chunfang, Westhorpe, Adam, Hall, Steven, Edge, Becky, Al Solaiss, Jaffer, Crittenden, Edouard, Marriott, Amy, Harrison, Robert, Kool, Jeroen and Casewell, Nicholas ORCID: (2022) 'In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus'. Toxicon, Vol 14, p. 100118.


Nys, Mieke, Zarkadas, Eleftherios, Brams, Marijke, Mehregan, Aujan, Kambara, Kumiko, Kool, Jeroen, Casewell, Nicholas ORCID:, Bertrand, Daniel, Baenziger, John E., Nury, Hugues and Ulens, Chris (2022) 'The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors'. Nature Communications, Vol 13, Issue 1, e4543.


Pardal, P. P. D., Souza, S. M., Monteiro, M. R. D. D., Fan, H. W., Cardoso, J. L. C., Franca, F. O. S., Tomy, S. C., Sano-Martins, I. S., de Sousa-E-Silva, M. C. C., Colombini, M., Kodera, N. F., Moura-Da-Silva, A. M., Cardoso, D. F., Velarde, D. T., Kamiguti, A. S., Theakston, R.David G. and Warrell, David A. (2004) 'Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 98, Issue 1, pp. 28-42.


Sells, Paula G. (2003) 'Animal experimentation in snake venom research and in vitro alternatives'. Toxicon, Vol 42, Issue 2, pp. 115-133.

Solano, Gabriela, Cunningham, Sinead, Edge, Becky, Duran, Gina, Sanchez, Adriana, Villalta, Mauren, Clare, Rachel ORCID:, Wilkinson, Mark ORCID:, Marriott, Amy, Abada, Camille, Menzies, Stefanie ORCID:, Keen, Molly, Lalloo, David ORCID:, Stienstra, Ymkje, Abouyannis, Michael ORCID:, Casewell, Nicholas ORCID:, León, Guillermo and Ainsworth, Stuart ORCID: (2024) 'African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages'. BMJ Global Health, Vol 9, Issue 3, e014813.


Theakston, R.David.G. and Laing, Gavin (2014) 'Diagnosis of Snakebite and the Importance of Immunological Tests in Venom Research'. Toxins, Vol 6, Issue 5, pp. 1667-1695.

This list was generated on Mon May 20 04:32:54 2024 BST.