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Skinner, Eloise B., Childs, Marissa L., Thomas, Matthew B., Cook, Jackie, Sternberg, Eleanore D., Koffi, Alphonsine A., N’Guessan, Raphael, Wolie, Rosine Z., Oumbouke, Welbeck, Ahoua Alou, Ludovic P., Brice, Serge and Mordecai, Erin A. (2024) 'Global malaria predictors at a localized scale'. Frontiers in Malaria, Vol 2.
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Abstract
Malaria is a life-threatening disease caused by Plasmodium parasites transmitted by Anopheles mosquitoes. In 2022, more than 249 million cases of malaria were reported worldwide, with an estimated 608,000 deaths. While malaria incidence has decreased globally in recent decades, some public health gains have plateaued, and many endemic hotspots still face high transmission rates. Understanding local drivers of malaria transmission is crucial but challenging due to the complex interactions between climate, entomological and human variables, and land use. This study focuses on highly climatically suitable and endemic areas in Côte d’Ivoire to assess the explanatory power of coarse climatic predictors of malaria transmission at a fine scale. Using data from 40 villages participating in a randomized controlled trial of a household malaria intervention, the study examines the effects of climate variation over time on malaria transmission. Through panel regressions and statistical modeling, the study investigates which variable (temperature, precipitation, or entomological inoculation rate) and its form (linear or unimodal) best explains seasonal malaria transmission and the factors predicting spatial variation in transmission. The results highlight the importance of temperature and rainfall, with quadratic temperature and all precipitation models performing well, but the causal influence of each driver remains unclear due to their strong correlation. Further, an independent, mechanistic temperature-dependent R0 model based on laboratory data, which predicts that malaria transmission peaks at 25°C and declines at lower and higher temperatures, aligns well with observed malaria incidence rates, emphasizing the significance and predictability of temperature suitability across scales. By contrast, entomological variables, such as entomological inoculation rate, were not strong predictors of human incidence in this context. Finally, the study explores the predictors of spatial variation in malaria, considering land use, intervention, and entomological variables. The findings contribute to a better understanding of malaria transmission dynamics at local scales, aiding in the development of effective control strategies in endemic regions.
| Item Type: | Article |
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| Subjects: | WA Public Health > Health Administration and Organization > WA 530 International health administration WA Public Health > Health Administration and Organization > WA 546 Local Health Administration. Community Health Services WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.3389/fmala.2024.1338648 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 02 Apr 2024 12:00 |
| Last Modified: | 02 Apr 2024 12:00 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/24280 |
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