Conflict and catastrophe-related severe burn injuries: A challenging setting for antimicrobial decision-making.

Pallett, Scott Jc, Mistry, Rakhee, Lambert, Zoe L, Woolley, Stephen, Abbara, Aula, Breathnach, Aodhan O, Lamb, Lucy E, Williams, Andrew, Mughal, Nabeela, Moshynets, Olena, Hughes, Stephen J, O'Shea, Matthew K and Moore, Luke Sp (2024) 'Conflict and catastrophe-related severe burn injuries: A challenging setting for antimicrobial decision-making.'. The Journal of infection, Vol 89, Issue 3, p. 106224.

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Abstract

Severe burns are a major component of conflict-related injuries and can result in high rates of mortality. Conflict and disaster-related severe burn injuries present unique challenges in logistic, diagnostic and treatment options, while wider conflict is associated with driving local antimicrobial resistance. We present a targeted review of available literature over the last 10 years on the use of systemic antimicrobial antibiotics in this setting and, given limited available data, provide an expert consensus discussion. While international guidelines do not tend to recommend routine use of prophylactic systemic antibiotics, the challenges of conflict settings and potential for polytrauma are likely to have ongoing impacts on antimicrobial decision-making and use. Efforts must be made to develop a suitable evidence base in this unique setting. In the interim, a pragmatic approach to balancing selective pressures of antimicrobial use with realistic access is possible.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole. WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Disorders and Injuries of Environmental Origin > WD 600 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.jinf.2024.106224
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	06 Aug 2024 13:27
Last Modified:	06 Aug 2024 13:27
URI:	https://archive.lstmed.ac.uk/id/eprint/24987

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